Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 김충현 | - |
dc.date.accessioned | 2019-05-23T06:25:21Z | - |
dc.date.available | 2019-05-23T06:25:21Z | - |
dc.date.issued | 2017-01 | - |
dc.identifier.citation | ONCOTARGET, v. 8, no. 4, page. 7003-7013 | en_US |
dc.identifier.issn | 1949-2553 | - |
dc.identifier.uri | http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=12273&path[]=38864 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/105929 | - |
dc.description.abstract | Purpose: Adoptive cell immunotherapy involves an ex vivo expansion of autologous cytokine-induced killer (CIK) cells before their reinfusion into the host. We evaluated the efficacy and safety of CIK cell immunotherapy with radiotherapy-temozolomide (TMZ) for the treatment of newly diagnosed glioblastomas.Experimental design: In this multi-center, open-label, phase 3 study, we randomly assigned patients with newly diagnosed glioblastoma to receive CIK cell immunotherapy combined with standard TMZ chemoradiotherapy (CIK immunotherapy group) or standard TMZ chemoradiotherapy alone (control group). The efficacy endpoints were analyzed in the intention-to-treat set and in the per protocol set.Results: Between December 2008 and October 2012, a total of 180 patients were randomly assigned to the CIK immunotherapy (n = 91) or control group (n = 89). In the intention-to-treat analysis set, median PFS was 8.1 months (95% confidence interval (CI), 5.8 to 8.5 months) in the CIK immunotherapy group, as compared to 5.4 months (95% CI, 3.3 to 7.9 months) in the control group (one-sided log-rank, p = 0.0401). Overall survival did not differ significantly between two groups. Grade 3 or higher adverse events, health-related quality of life and performance status between two groups did not show a significant difference.Conclusions: The addition of CIK cells immunotherapy to standard chemoradiotherapy with TMZ improved PFS. However, the CIK immunotherapy group did not show evidence of a beneficial effect on overall survival. | en_US |
dc.description.sponsorship | Supported by Green Cross Cell Corp (Seoul, Korea). This study was designed by the sponsor in conjunction with the principal academic investigators. Data were managed in parallel by the sponsor and the principal investigators. | en_US |
dc.language.iso | en | en_US |
dc.publisher | IMPACT JOURNALS LLC | en_US |
dc.subject | immunotherapy | en_US |
dc.subject | autologous cytokine-induced killer cell | en_US |
dc.subject | glioblastoma | en_US |
dc.title | Phase III randomized trial of autologous cytokine-induced killer cell immunotherapy for newly diagnosed glioblastoma in korea | en_US |
dc.type | Article | en_US |
dc.relation.no | 4 | - |
dc.relation.volume | 8 | - |
dc.identifier.doi | 10.18632/oncotarget.12273 | - |
dc.relation.page | 7003-7013 | - |
dc.relation.journal | ONCOTARGET | - |
dc.contributor.googleauthor | Kong, Doo-Sik | - |
dc.contributor.googleauthor | Nam, Do-Hyun | - |
dc.contributor.googleauthor | Kang, Shin-Hyuk | - |
dc.contributor.googleauthor | Lee, Jae Won | - |
dc.contributor.googleauthor | Chang, Jong-Hee | - |
dc.contributor.googleauthor | Kim, Jeong-Hoon | - |
dc.contributor.googleauthor | Lim, Young-Jin | - |
dc.contributor.googleauthor | Koh, Young-Cho | - |
dc.contributor.googleauthor | Chung, Yong-Gu | - |
dc.contributor.googleauthor | Kim, Choong-Hyun | - |
dc.relation.code | 2017009424 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | kch5142 | - |
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