Total Synthesis and Biological Evaluation of Sericetin for Protection against Cisplatin-Induced Acute Kidney Injury
- Title
- Total Synthesis and Biological Evaluation of Sericetin for Protection against Cisplatin-Induced Acute Kidney Injury
- Author
- 배옥남
- Keywords
- PRENYLATED FLAVONOIDS; INDUCED NEPHROTOXICITY; OXIDATIVE STRESS; MACAKURZIN C; CELL-DEATH; IN-VITRO; INFLAMMATION; INHIBITION; MECHANISMS; APOPTOSIS
- Issue Date
- 2018-12
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF NATURAL PRODUCTS, v. 81, No. 12, Page. 2647-2653
- Abstract
- A concise synthesis of sericetin (1) was performed in four steps from readily available 3-Obenzylgalangin (4), featuring electrocyclization to produce
the tricyclic core and a sequential aromatic Claisen/Cope rearrangement to incorporate the 8-prenyl group of 1. In addition, the therapeutic potential of sericetin (1), isosericetin (2), and three prenylated tetracyclic synthetic intermediates (11, 12, and 14) against cisplatin-induced nephrotoxicity using renal tubular cells were evaluated. Compound 14 showed therapeutic potential against cisplatin-induced kidney damage.
- URI
- https://pubs.acs.org/doi/abs/10.1021/acs.jnatprod.8b00434https://repository.hanyang.ac.kr/handle/20.500.11754/105798
- ISSN
- 0163-3864; 1520-6025
- DOI
- 10.1021/acs.jnatprod.8b00434
- Appears in Collections:
- COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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