Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 배옥남 | - |
dc.date.accessioned | 2019-05-22T06:56:22Z | - |
dc.date.available | 2019-05-22T06:56:22Z | - |
dc.date.issued | 2018-06 | - |
dc.identifier.citation | STROKE, v. 49, No. 6, Page. 1571-1579 | en_US |
dc.identifier.issn | 0039-2499 | - |
dc.identifier.uri | https://www.ahajournals.org/doi/abs/10.1161/strokeaha.117.017287 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/105596 | - |
dc.description.abstract | The global burden of neurological diseases including stroke has significantly increased, 1 and an urgent need exists to develop new treatment strategies. Impairment of autophagic regulation has been observed in diseases including neurodegenerative diseases and ischemic stroke, suggesting that modulation of autophagy could be a potential therapeutic target. 2 Endothelial cells (ECs) maintain homeostasis by regulating the vascular tone and permeability and endothelial dysfunction is associated with diverse cardiovascular diseases (CVDs). The integrity of the blood-brain barrier (BBB), which shows selective permeability for substances into the brain, is significantly impaired under ischemic stroke. This review focuses on autophagy in endothelial dysfunction in the context of ischemic stroke and potential targets for therapeutic manipulation. | en_US |
dc.description.sponsorship | This study was supported by grants from the Ministry of Health and Welfare (HI14C2180) and from the National Research Foundation (NRF-2017R1C1B3002626) of Korea. This article was partially prepared at the National Institute for Health Research (NIHR) Sheffield Biomedical Research Centre (Translational Neuroscience). The views expressed are those of the author(s) and not necessarily those of the NIHR. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | American Heart Association | en_US |
dc.subject | autophagy | en_US |
dc.subject | blood-brain barrier | en_US |
dc.subject | disease progression | en_US |
dc.subject | endothelial cells | en_US |
dc.subject | endothelial progenitor cells | en_US |
dc.title | Role of Autophagy in Endothelial Damage and Blood-Brain Barrier Disruption in Ischemic Stroke | en_US |
dc.type | Article | en_US |
dc.relation.no | 6 | - |
dc.relation.volume | 49 | - |
dc.identifier.doi | 10.1161/STROKEAHA.117.017287 | - |
dc.relation.page | 1571-1579 | - |
dc.relation.journal | STROKE | - |
dc.contributor.googleauthor | Kim, Kyeong-A | - |
dc.contributor.googleauthor | Shin, Donggeun | - |
dc.contributor.googleauthor | Kim, Jeong-Hyeon | - |
dc.contributor.googleauthor | Shin, Young-Jun | - |
dc.contributor.googleauthor | Rajanikant, G. K. | - |
dc.contributor.googleauthor | Majid, Arshad | - |
dc.contributor.googleauthor | Baek, Seung-Hoon | - |
dc.contributor.googleauthor | Bae, Ok-Nam | - |
dc.relation.code | 2018002928 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | onbae | - |
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