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dc.contributor.author이영식-
dc.date.accessioned2019-05-22T06:20:25Z-
dc.date.available2019-05-22T06:20:25Z-
dc.date.issued2018-05-
dc.identifier.citationBIOMOLECULES & THERAPEUTICS, v. 26, No. 3, Page. 290-297en_US
dc.identifier.issn1976-9148-
dc.identifier.urihttp://www.biomolther.org/journal/view.html?uid=954&vmd=Full-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/105509-
dc.description.abstractWe aimed to understand the molecular changes in host cells that accompany infection by the seasonal influenza A H1N1 virus because the initial response rapidly changes owing to the fact that the virus has a robust initial propagation phase. Human epithelial alveolar A549 cells were infected and total RNA was extracted at 30 min, 1 h, 2 h, 4 h, 8 h, 24 h, and 48 h post infection (h.p.i.). The differentially expressed host genes were clustered into two distinct sets of genes as the infection progressed over time. The patterns of expression were significantly different at the early stages of infection. One of the responses showed roles similar to those associated with the enrichment gene sets to known 'gp120 pathway in HIV.' This gene set contains genes known to play roles in preventing the progress of apoptosis, which infected cells undergo as a response to viral infection. The other gene set showed enrichment of 'Drug Metabolism Enzymes (DMEs).' The identification of two distinct gene sets indicates that the virus regulates the cell's mechanisms to create a favorable environment for its stable replication and protection of gene metabolites within 8 h.en_US
dc.description.sponsorshipWe thank Dr. Hueeman Kim for his advice regarding experimental design. This research was funded by the post-genome multi-ministerial genome project (NRF-2014M3C9A3064815) of the Ministry of Science, ICT, and Future Planning, Republic of Korea. This research was supported by National Cancer Center Grant (NCC-1711290).en_US
dc.language.isoen_USen_US
dc.publisherKOREAN SOC APPLIED PHARMACOLOGYen_US
dc.subjectA549 Cellsen_US
dc.subjectInfluenza A virus H1N1 subtypeen_US
dc.subjectHigh-throughput nucleotide sequencingen_US
dc.subjectSequence analysis RNAen_US
dc.subjectApoptosisen_US
dc.subjectGene expression regulationen_US
dc.titleConstruction of a Transcriptome-Driven Network at the Early Stage of Infection with Influenza A H1N1 in Human Lung Alveolar Epithelial Cellsen_US
dc.typeArticleen_US
dc.relation.no3-
dc.relation.volume26-
dc.identifier.doi10.4062/biomolther.2017.240-
dc.relation.page290-297-
dc.relation.journalBIOMOLECULES & THERAPEUTICS-
dc.contributor.googleauthorChung, Myungguen-
dc.contributor.googleauthorCho, Soo Young-
dc.contributor.googleauthorLee, Young Seek-
dc.relation.code2018008614-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E]-
dc.sector.departmentDEPARTMENT OF MOLECULAR AND LIFE SCIENCE-
dc.identifier.pidyslee-


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