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dc.contributor.author최한곤-
dc.date.accessioned2019-05-20T07:11:57Z-
dc.date.available2019-05-20T07:11:57Z-
dc.date.issued2008-10-
dc.identifier.citation약제학회지, v. 38, No. 5, Page. 289-293en_US
dc.identifier.issn2093-5552-
dc.identifier.urihttp://kiss.kstudy.com/thesis/thesis-view.asp?key=2730462-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/104968-
dc.description.abstractTo develop a poloxamer-based solid suppository with poloxamer and polyethylene glycol mixtures, the melting point of various formulations composed of P 188 and propylene glycol were investigated. The dissolution and antitumor activity of clotrimazole delivered by the poloxamer-based suppository were performed. The poloxamer mixtures composed of P 188 and propylene glycol were homogeneous phases. P 188 greatly affected the melting point of poloxamer mixtures. In particular, the poloxamer mixture [P 188/propylene glycol(70/30%)] with the melting point of about was a solid form at room temperature and instantly melted at physiological temperature. Furthermore, the ratio of P 188/propylene glycol greatly affected the dissolution rates of clotrimazole from poloxamer-based suppository. It gave the more effective anti-tumor activity than conventional PEG-based suppository due to fast dissolution. Thus, the clotrimazole-Ioaded poloxamer-based solid suppository was an effective rectal dosage form with anti-tumor activity.en_US
dc.language.isoen_USen_US
dc.publisher한국약제학회en_US
dc.subjectClotrimazoleen_US
dc.subjectSuppositoryen_US
dc.subjectAnti-tumor activityen_US
dc.titleA Novel Clotrimazole-loaded Suppository with Effective Anti-tumor Activityen_US
dc.typeArticleen_US
dc.relation.no5-
dc.relation.volume38-
dc.relation.page289-293-
dc.relation.journal약제학회지-
dc.contributor.googleauthorXuan, Jing Ji-
dc.contributor.googleauthorKim, Jong-Tae-
dc.contributor.googleauthorOh, Dong-Hoon-
dc.contributor.googleauthorHan, Hong-Hee-
dc.contributor.googleauthorLee, Won-Seok-
dc.contributor.googleauthorLee, Jong-Sook-
dc.contributor.googleauthorRhee, Jong-Dal-
dc.contributor.googleauthorYong, Chul-Soon-
dc.contributor.googleauthorWoo, Jong-Soo-
dc.contributor.googleauthorKim, Jung-Ae-
dc.contributor.googleauthorChoi, Han-Gon-
dc.relation.code2012215153-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidhangon-
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COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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