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A Novel Clotrimazole-loaded Suppository with Effective Anti-tumor Activity

Title
A Novel Clotrimazole-loaded Suppository with Effective Anti-tumor Activity
Author
최한곤
Keywords
Clotrimazole; Suppository; Anti-tumor activity
Issue Date
2008-10
Publisher
한국약제학회
Citation
약제학회지, v. 38, No. 5, Page. 289-293
Abstract
To develop a poloxamer-based solid suppository with poloxamer and polyethylene glycol mixtures, the melting point of various formulations composed of P 188 and propylene glycol were investigated. The dissolution and antitumor activity of clotrimazole delivered by the poloxamer-based suppository were performed. The poloxamer mixtures composed of P 188 and propylene glycol were homogeneous phases. P 188 greatly affected the melting point of poloxamer mixtures. In particular, the poloxamer mixture [P 188/propylene glycol(70/30%)] with the melting point of about was a solid form at room temperature and instantly melted at physiological temperature. Furthermore, the ratio of P 188/propylene glycol greatly affected the dissolution rates of clotrimazole from poloxamer-based suppository. It gave the more effective anti-tumor activity than conventional PEG-based suppository due to fast dissolution. Thus, the clotrimazole-Ioaded poloxamer-based solid suppository was an effective rectal dosage form with anti-tumor activity.
URI
http://kiss.kstudy.com/thesis/thesis-view.asp?key=2730462https://repository.hanyang.ac.kr/handle/20.500.11754/104968
ISSN
2093-5552
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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