Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이수재 | - |
dc.date.accessioned | 2019-05-13T08:21:30Z | - |
dc.date.available | 2019-05-13T08:21:30Z | - |
dc.date.issued | 2019-02 | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF NANOMEDICINE, Page. 1131-1148 | en_US |
dc.identifier.issn | 1178-2013 | - |
dc.identifier.uri | https://www.dovepress.com/gold-quantum-dots-impair-the-tumorigenic-potential-of-glioma-stem-like-peer-reviewed-article-IJN | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/104083 | - |
dc.description.abstract | Background Over the past several decades, the incidence of solid cancers has rapidly increased worldwide. Successful removal of tumor-initiating cells within tumors is essential in the field of cancer therapeutics to improve patient disease-free survival rates. The biocompatible multivarient-sized gold nanoparticles (MVS-GNPs) from quantum dots (QDs, <10 nm) to nanosized (up to 50 nm) particles have vast applications in various biomedical areas including cancer treatment. The role of MVS-GNPs for inhibition of tumorigenic potential and stemness of glioma was investigated in this study. Methods Herein, MVS-GNPs synthesized and characterized by means of X-ray diffraction pattern (XRD) and transmission electron microscopy (TEM) techniques. Afterwards, interaction of these GNPs with glioma stem-cell like cells along with cancer cells were evaluated by MTT, cell motility, self-renewal assays and biostatistics was also applied. Results Among these GNPs, G-QDs contributed to reduce metastatic events and spheroid cell growth, potentially blocking the self-renewal ability of these cells. This study also uncovers the previously unknown role of the inhibition of CTNNB1 signaling as a novel candidate to decrease the tumorigenesis of glioma spheroids and subsequent spheroid growth. The accurate and precise biostatistics results were obtained at quantify level. Conclusion In summary, G-QDs may exhibit possible contribution on suppressing the growth of tumor-initiating cells. These data reveal a unique therapeutic approach for the elimination of residual resistant stem-like cells during cancer treatment. | en_US |
dc.description.sponsorship | This study was financially supported by the King Saud University, Vice Deanship of Research Chairs. This work was supported by a grant from the National Research Foundation of Korea (NRF), which is funded by the Korean Government, Ministry of Science, ICT and Future Planning (MSIP) NRF-2016K1A4A3914113 and NRF-2016R1C1B2010851. This work is also supported by Kwangwoon University Research Grant in 2018–19. This research was also supported by the Bio & Medical Technology Development Program of the NRF funded by MSIP (No-2017M3A9G8084539). | en_US |
dc.language.iso | en | en_US |
dc.publisher | DOVE MEDICAL PRESS LTD | en_US |
dc.subject | multivarient gold nanoparticles | en_US |
dc.subject | epithelial-mesenchymal transition | en_US |
dc.subject | solid tumor | en_US |
dc.subject | brain cancer | en_US |
dc.subject | self-renewal | en_US |
dc.subject | cellular movement | en_US |
dc.subject | biostatistics | en_US |
dc.title | Gold quantum dots impair the tumorigenic potential of glioma stem-like cells via β-catenin downregulation in vitro | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.2147/IJN.S195333 | - |
dc.relation.page | 1131-1148 | - |
dc.relation.journal | INTERNATIONAL JOURNAL OF NANOMEDICINE | - |
dc.contributor.googleauthor | Wahab, Rizwan | - |
dc.contributor.googleauthor | Kaushik, Neha | - |
dc.contributor.googleauthor | Khan, Farheen | - |
dc.contributor.googleauthor | Kaushik, Nagendra Kumar | - |
dc.contributor.googleauthor | Lee, Su-Jae | - |
dc.contributor.googleauthor | Choi, Eun Ha | - |
dc.contributor.googleauthor | Al-Khedhairy, Abdulaziz A | - |
dc.relation.code | 2019001001 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF NATURAL SCIENCES[S] | - |
dc.sector.department | DEPARTMENT OF LIFE SCIENCE | - |
dc.identifier.pid | sj0420 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.