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dc.contributor.author김철영-
dc.date.accessioned2019-05-09T07:18:17Z-
dc.date.available2019-05-09T07:18:17Z-
dc.date.issued2017-10-
dc.identifier.citationDRUG DESIGN DEVELOPMENT AND THERAPY, v. 11, Page. 2969-2979en_US
dc.identifier.issn1177-8881-
dc.identifier.urihttps://www.dovepress.com/protective-effect-of-da-9401-in-finasteride-induced-apoptosis-in-rat-t-peer-reviewed-article-DDDT-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/103685-
dc.description.abstractFinasteride is used to treat male pattern baldness and benign prostatic hyperplasia. This study investigated the toxicity of finasteride and recovery by DA-9401 using Sprague Dawley (SD) rats. Forty adult male SD rats were assigned to four groups: control (CTR), finasteride 1 mg/kg/day (F), finasteride 1 mg/kg + DA-9401 100 mg/kg/day (F + DA 100) and finasteride 1 mg/kg + DA-9401 200 mg/kg/day (F + DA 200). Treatments were by oral delivery once daily for 90 consecutive days. The gross anatomical parameters assessed included: genital organ weight; vas deferens sperm count and sperm motility; testosterone, dihydrotestosterone (DHT) and malondialdehyde levels; and histological and terminal deoxynucleotidyl transferase enzyme mediated dUTP nick-end labeling (TUNEL) staining of testis for spermatogenic cell density, Johnsen’s score and apoptosis. Testicular tissue was also used for evaluating endoplasmic reticulum (ER) stress and apoptotic proteins. Epididymis weight, seminal vesicle weight, prostate weight, penile weight and vas deferens sperm motility showed significant differences between the F group and the CTR, F + DA 100 and F + DA 200 groups. There was no significant change in the testosterone level. DHT level decreased significantly in the F group compared with the CTR group. Testis tissue revealed significant changes in spermatogenic cell density, Johnsen’s score and apoptotic index. Western blot showed significant changes in the ER stress and apoptotic markers. Finasteride resulted in reduced fertility and increased ER stress and apoptotic markers, which were recovered by administration of DA-9401 in the SD rats.en_US
dc.description.sponsorshipThis study was supported by grants from the Korean Healthcare Technology R&D Project, Ministry for Health, Welfare, & Family Affairs, Republic of Korea (HI14C0018). The Korean Healthcare Technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea had no role in the design or conduct of the study; collection, management, analysis, or interpretation of the data; or preparation, review, or approval of the manuscript. The content of this article is solely the responsibility of the authors and does not necessarily represent the official views of the Korean Healthcare Technology R&D Project, Ministry for Health, Welfare, & Family Affairs, Republic of Korea. All researchers received support from this grant, but there are no financial or other potential conflicts of interest to declare.en_US
dc.language.isoen_USen_US
dc.publisherDOVE MEDICAL PRESS LTDen_US
dc.subjectfinasterideen_US
dc.subjectDA-9401en_US
dc.subjectinfertilityen_US
dc.subjectspermen_US
dc.subjectdihydrotestosteroneen_US
dc.subjectendoplasmic reticulum stressen_US
dc.subjectapoptosisen_US
dc.titleProtective effect of DA-9401 in finasteride-induced apoptosis in rat testis: inositol requiring kinase 1 and c-Jun N-terminal kinase pathwayen_US
dc.typeArticleen_US
dc.relation.volume11-
dc.identifier.doi10.2147/DDDT.S140543-
dc.relation.page2969-2979-
dc.relation.journalDRUG DESIGN DEVELOPMENT AND THERAPY-
dc.contributor.googleauthorSoni, Kiran Kumar-
dc.contributor.googleauthorShin, Yu Seob-
dc.contributor.googleauthorChoi, Bo Ram-
dc.contributor.googleauthorKarna, Keshab Kumar-
dc.contributor.googleauthorKim, Hye Kyung-
dc.contributor.googleauthorLee, Sung Won-
dc.contributor.googleauthorKim, Chul Young-
dc.contributor.googleauthorPark, Jong Kwan-
dc.relation.code2017010428-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidchulykim-
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COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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