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Neonatal diffusion tensor brain imaging predicts later motor outcome in preterm neonates with white matter abnormalities

Title
Neonatal diffusion tensor brain imaging predicts later motor outcome in preterm neonates with white matter abnormalities
Author
박현경
Keywords
Neonates; Magnetic resonance imaging; Diffusion tensor imaging; Periventricular leukomalacia
Issue Date
2016-12
Publisher
BIOMED CENTRAL LTD
Citation
ITALIAN JOURNAL OF PEDIATRICS, v. 42, Page. 104-110
Abstract
Background: White matter (WM) abnormalities associated with prematurity are one of the most important causes of neurological disability that involves spastic motor deficits in preterm newborns. This study aimed to evaluate regional microstructural changes in diffusion tensor imaging (DTI) associated with WM abnormalities. Methods: We prospectively studied extremely low birth weight (ELBW; < 1000 g) preterm infants who were admitted to the Neonatal Intensive Care Unit of Hanyang University Hospital between February 2011 and February 2014. WM abnormalities were assessed with conventional magnetic resonance (MR) imaging and DTI near term-equivalent age before discharge. Region-of-interests (ROIs) measurements were performed to examine the regional distribution of fractional anisotropy (FA) values. Results: Thirty-two out of 72 ELBW infants underwent conventional MR imaging and DTI at term-equivalent age. Ten of these infants developed WM abnormalities associated with prematurity. Five of ten of those with WM abnormalities developed cerebral palsy (CP). DTI in the WM abnormalities with CP showed a significant reduction of mean FA in the genu of the corpus callosum (p = 0.022), the ipsilateral posterior limb of the internal capsule (p = 0. 019), and the ipsilateral centrum semiovale (p = 0.012) compared to normal WM and WM abnormalities without CP. In infants having WM abnormalities with CP, early FA values in neonatal DTI revealed abnormalities of the WM regions prior to the manifestation of hemiparesis. Conclusions: DTI performed at term equivalent age shows different FA values in WM regions among infants with or without WM abnormalities associated with prematurity and/or CP. Low FA values of ROIs in DTI are related with later development of spastic CP in preterm infants with WM abnormalities.
URI
https://ijponline.biomedcentral.com/articles/10.1186/s13052-016-0309-9https://repository.hanyang.ac.kr/handle/20.500.11754/102927
ISSN
1720-8424; 1824-7288
DOI
10.1186/s13052-016-0309-9
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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