168 52

새로운 COX-2 억제제

Title
새로운 COX-2 억제제
Other Titles
New COX-2 Inhibitors
Author
성윤경
Keywords
비스테로이드 소염제; 사이클로옥시제나제 저해제; 안전성; Anti-inflammatory agents; Non-steroidal; Cyclooxygenase inhibitors; Safety
Issue Date
2016-12
Publisher
대한내과학회
Citation
대한내과학회지, v. 91, NO 3, Page. 250-256
Abstract
Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat pain and inflammation. There are two kinds of NSAID classified according to the selectivity of COX-2 inhibition: non-selective NSAIDs and cyclooxygenase (COX)-2 inhibitors. Non-selective NSAIDs have a high incidence of gastrointestinal and bleeding-associated adverse events, while COX-2 inhibitors are safer in terms of these events. However, COX-2 inhibitors are thought to cause increased cardiovascular events. The COX-2 inhibitors rofecoxib and valdecoxib were withdrawn from the market over safety concerns. Three COX-2 inhibitors are now available in South Korea after the recent approval of etoricoxib and polmacoxib for osteoarthritis patients. After reviewing the history of and recent studies about the safety of COX-2 inhibitors, physicians should find new uses for old drugs. (Korean J Med 2016;91:250-256)
URI
http://ekjm.org/journal/view.php?doi=10.3904/kjm.2016.91.3.250https://repository.hanyang.ac.kr/handle/20.500.11754/102924
ISSN
1738-9364; 2289-0769
DOI
10.3904/kjm.2016.91.3.250
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
Files in This Item:
새로운 COX-2 억제제.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE