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dc.contributor.author류종석-
dc.date.accessioned2019-04-24T04:44:59Z-
dc.date.available2019-04-24T04:44:59Z-
dc.date.issued2016-09-
dc.identifier.citationJOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v. 26, No. 9, Page. 1657-1660en_US
dc.identifier.issn1017-7825-
dc.identifier.issn1738-8872-
dc.identifier.urihttp://www.jmb.or.kr/journal/view.html?doi=10.4014/jmb.1601.01057-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/102713-
dc.description.abstractPrion diseases are incurable neurodegenerative disorders. Our previous study demonstrated that polylysine was effective in prolonging the incubation period in a rodent model and in alleviating the scrapie prion protein (PrPSc) burden in the brain at the terminal stage of the disease. Here, we report that intraperitoneal administration of polylysine suppresses the accumulation of prions in the spleen during the early stages of the disease. This study supports the congruence of PrPSc inhibition by polylysine in both the spleen and brain.en_US
dc.description.sponsorshipThis study was partly support by a research fund from Hanyang University (HYU-2012-G).en_US
dc.language.isoen_USen_US
dc.publisherKOREAN SOC MICROBIOLOGY & BIOTECHNOLOGYen_US
dc.subjectPrionen_US
dc.subjectPrPScen_US
dc.subjectanimal modelen_US
dc.subjectspleenen_US
dc.subjectbrainen_US
dc.subjectpolylysineen_US
dc.titleEffect of Polylysine on Scrapie Prion Protein Propagation in Spleen during Asymptomatic Stage of Experimental Prion Disease in Miceen_US
dc.typeArticleen_US
dc.relation.no9-
dc.relation.volume26-
dc.identifier.doi10.4014/jmb.1601.01057-
dc.relation.page1657-1660-
dc.relation.journalJOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY-
dc.contributor.googleauthorTitlow, WB-
dc.contributor.googleauthorWaqas, M-
dc.contributor.googleauthorLee, J-
dc.contributor.googleauthorCho, JY-
dc.contributor.googleauthorLee, SY-
dc.contributor.googleauthorKim, DH-
dc.contributor.googleauthorRyou, CS-
dc.relation.code2016006799-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidcryou2-
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COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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