60 0

Full metadata record

DC FieldValueLanguage
dc.contributor.author최한곤-
dc.date.accessioned2019-04-23T05:54:23Z-
dc.date.available2019-04-23T05:54:23Z-
dc.date.issued2016-07-
dc.identifier.citationINTERNATIONAL JOURNAL OF NANOMEDICINE, v. 11, Page. 2799-2813en_US
dc.identifier.issn1178-2013-
dc.identifier.urihttps://www.dovepress.com/receptor-targeted-drug-loaded-functionalized-graphene-oxides-for-chemo-peer-reviewed-article-IJN-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/102593-
dc.description.abstractCancer is one of the leading causes of death worldwide. Although different chemotherapeutic agents have been developed to treat cancers, their use can be limited by low cellular uptake, drug resistance, and side effects. Hence, targeted drug delivery systems are continually being developed in order to improve the efficacy of chemotherapeutic agents. The main aim of this study was to prepare folic acid (FA)-conjugated polyvinyl pyrrolidone-functionalized graphene oxides (GO) (FA-GO) for targeted delivery of sorafenib (SF). GO were prepared using a modified Hummer's method and subsequently altered to prepare FA-GO and SF-loaded FA-GO (FA-GO/SF). Characterization of GO derivatives was done using ultraviolet/visible spectroscopy, Fourier transform infrared spectroscopy, X-ray diffraction, atomic force microscopy, zeta potential measurements, and determination of in vitro drug release. Hemolytic toxicity, in vitro cytotoxicity, cellular uptake, and apoptotic effects of FA-GO/SF were also investigated. The results revealed that GO was successfully synthesized and that further transformation to FA-GO improved the stability and SF drug-loading capacity. In addition, the enhanced SF release under acidic conditions suggested possible benefits for cancer treatment. Conjugation of FA within the FA-GO/SF delivery system enabled targeted delivery of SF to cancer cells expressing high levels of FA receptors, thus increasing the cellular uptake and apoptotic effects of SF. Furthermore, the photothermal effect achieved by exposure of GO to near-infrared irradiation enhanced the anticancer effects of FA-GO/SF. Taken together, FA-GO/SF is a potential carrier for targeted delivery of chemotherapeutic agents in cancer.en_US
dc.description.sponsorshipThis research was supported by the National Research Foundation of Korea (NRF) grant (2015R1A2A2A01004118, 2015R1A2A2A04004806) and the Medical Research Center Program (2015R1A5A2009124) funded by the Korea government (MSIP).en_US
dc.language.isoen_USen_US
dc.publisherDOVE MEDICAL PRESS LTDen_US
dc.subjectgraphene oxideen_US
dc.subjectfolic aciden_US
dc.subjectsorafeniben_US
dc.subjecttargeted drug deliveryen_US
dc.subjectnear-infrareden_US
dc.titleReceptor-targeted, drug-loaded, functionalized graphene oxides for chemotherapy and photothermal therapyen_US
dc.typeArticleen_US
dc.relation.volume11-
dc.identifier.doi10.2147/IJN.S105401-
dc.relation.page2799-2813-
dc.relation.journalINTERNATIONAL JOURNAL OF NANOMEDICINE-
dc.contributor.googleauthorThapa, RK-
dc.contributor.googleauthorChoi, JY-
dc.contributor.googleauthorPoudel, BK-
dc.contributor.googleauthorChoi, HG-
dc.contributor.googleauthorYong, CS-
dc.contributor.googleauthorKim, JO-
dc.relation.code2016000827-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidhangon-
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE