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Roles and epigenetic regulation of epithelial-mesenchymal transition and its transcription factors in cancer initiation and progression

Title
Roles and epigenetic regulation of epithelial-mesenchymal transition and its transcription factors in cancer initiation and progression
Author
공구
Keywords
EMT; EMT transcription factor; Human cancer; Epigenetics; Chromatin; Histone modification; DNA methylation
Issue Date
2016-12
Publisher
SPRINGER BASEL AG
Citation
CELLULAR AND MOLECULAR LIFE SCIENCES, v. 73, Issue 24, Page. 4643-4660
Abstract
The epithelial-mesenchymal transition (EMT) is a crucial developmental process by which epithelial cells undergo a mesenchymal phenotypic change. During EMT, epigenetic mechanisms including DNA methylation and histone modifications are involved in the regulation of EMT-related genes. The epigenetic gene silencing of the epithelial marker E-cadherin has been well characterized. In particular, three major transcriptional repressors of E-cadherin, Snail, ZEB, and Twist families, also known as EMT-inducing transcription factors (EMT-TFs), play a crucial role in this process by cooperating with multiple epigenetic modifiers. Furthermore, recent studies have identified the novel epigenetic modifiers that control the expression of EMT-TFs, and these modifiers have emerged as critical regulators of cancer development and as novel therapeutic targets for human cancer. In this review, the diverse functions of EMT-TFs in cancer progression, the cooperative mechanisms of EMT-TFs with epigenetic modifiers, and epigenetic regulatory roles for the expression of EMT-TFs will be discussed.
URI
https://link.springer.com/article/10.1007%2Fs00018-016-2313-zhttps://repository.hanyang.ac.kr/handle/20.500.11754/102344
ISSN
1420-682X; 1420-9071
DOI
10.1007/s00018-016-2313-z
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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