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dc.contributor.author박용천-
dc.date.accessioned2019-04-18T06:16:06Z-
dc.date.available2019-04-18T06:16:06Z-
dc.date.issued2016-12-
dc.identifier.citationACTA NEUROPSYCHIATRICA, V. 28, NO 6, Page. 337-345en_US
dc.identifier.issn1601-5215-
dc.identifier.urihttps://www.cambridge.org/core/journals/acta-neuropsychiatrica/article/suicidal-thoughtsacts-and-clinical-correlates-in-patients-with-depressive-disorders-in-asians-results-from-the-reapad-study/4860D3599EEFAD4AA005956F46CA1843-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/102331-
dc.description.abstractObjective: Using data from the Research on Asian Psychotropic Prescription Patterns for Antidepressants (REAP-AD) study, we aimed to present the rates and clinical correlates of suicidal thoughts/acts in patients recruited from a total of 40 centres in 10 Asian countries/areas: China, Hong Kong, India, Indonesia, Japan, Korea, Malaysia, Singapore, Taiwan, and Thailand. Methods: Data from 1122 patients with depressive disorders in the REAP-AD study were used. The ICD-10 was employed to diagnose depressive episodes and recurrent depressive disorder. The presence or absence of suicidal thoughts/acts and profile of other depressive symptoms was established using the National Institute for Health and Clinical Excellence guidelines for depression. Country/area differences in rates of suicidal thoughts/acts were evaluated with the chi(2) test. In addition, depressive symptom profiles, other clinical characteristics, and patterns of psychotropic drug prescription in depressed patients with and without suicidal thoughts/acts were compared using analysis of covariance for continuous variables and logistic regression analysis for discrete variables to adjust the effects of covariates. Results: The rates of suicidal thoughts/acts in 10 countries/areas varied from 12.8% in Japan to 36.3% in China. Patients with suicidal thoughts/acts presented more persistent sadness (adjusted odds ratio [aOR] = 2.64, p˂0.001), loss of interest (aOR = 2.33, p˂0.001), fatigue (aOR = 1.58, p˂0.001), insomnia (aOR = 1.74, p˂0.001), poor concentration (aOR = 1.88, p˂0.001), low self-confidence (aOR = 1.78, p˂0.001), poor appetite (aOR = 2.27, p˂0.001), guilt/self-blame (aOR = 3.03, p˂0.001), and use of mood stabilisers (aOR = 1.79, p˂0.001) than those without suicidal thoughts/acts. Conclusion: Suicidal thoughts/acts can indicate greater severity of depression, and are associated with a poorer response to antidepressants and increased burden of illness. Hence, suicidal thoughts/acts can provide a clinical index reflecting the clinical status of depressive disorders in Asians.en_US
dc.language.isoenen_US
dc.publisherCAMBRIDGE UNIV PRESSen_US
dc.subjectAsiansen_US
dc.subjectdepressive disordersen_US
dc.subjectmood stabilisersen_US
dc.subjectsuicidal thoughts/actsen_US
dc.titleSuicidal thoughts/acts and clinical correlates in patients with depressive disorders in Asians: results from the REAP-AD studyen_US
dc.typeArticleen_US
dc.relation.no6-
dc.relation.volume28-
dc.identifier.doi10.1017/neu.2016.27-
dc.relation.page337-345-
dc.relation.journalACTA NEUROPSYCHIATRICA-
dc.contributor.googleauthorPark, Seon-Cheol-
dc.contributor.googleauthorLee, Min-Soo-
dc.contributor.googleauthorHahn, Sang Woo-
dc.contributor.googleauthorSi, Tian-Mei-
dc.contributor.googleauthorKanba, Shigenobu-
dc.contributor.googleauthorChong, Mian-Yoon-
dc.contributor.googleauthorYoon, Chee Kok-
dc.contributor.googleauthorUdomratn, Pichet-
dc.contributor.googleauthorTripathi, Adarsh-
dc.contributor.googleauthorPark, Yong Chon-
dc.relation.code2016009561-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidhypyc-
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