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dc.contributor.author김철영-
dc.date.accessioned2019-04-15T02:30:40Z-
dc.date.available2019-04-15T02:30:40Z-
dc.date.issued2015-11-
dc.identifier.citationJOURNAL OF SEXUAL MEDICINE, v. 12, No. 11, Page. 2134-2140en_US
dc.identifier.issn1743-6095-
dc.identifier.issn1743-6109-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1743609515344519-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/101885-
dc.description.abstractIntroduction. Ejaculation dysfunction is one of the most common male sexual disorders. Despite its prevalence and adverse impact on patients, little attention has been given to investigating ejaculation dysfunction. Aim. We introduce a new method for evaluating ejaculation dysfunction in rats with a telemetric device. Methods. A pressure transducer was surgically implanted in the seminal vesicles of 7-week-old male Sprague-Dawley rats. One week later, the rats were subcutaneously administered tamsulosin 3 mu g/kg, and intra-seminal vesicle pressure (ISVP) was recorded in freely moving rats after an injection of apomorphine (80 mu g/kg). Same rats repeated experiment with tamsulosin 10 mu g/kg, silodosin 1 mg/kg, and normal saline with 3-day intervals. Main Outcome Measure. Sexual events were visually identified and recorded. Ejaculation was confirmed by visualization of a copulatory plug in the tip of the penis. We compared the maximal ISVP and area under the curve (AUC) of the ISVP. Results. Adequate ISVP data were easily recorded and available in 66.6% rats (10/15) over a 6-week telemetric recording period (12 recordings). The mean number of ejaculations during an inspection time of 30 minutes was 1.5 +/- 0.1. The maximal ISVP values in rats receiving 3 mu g/kg (30.0 +/- 5.2 mm Hg) and 10 mu g/kg tamsulosin (15.1 +/- 1.6 mm Hg) and 1 mg/kg silodosin (12.9 +/- 2.2 mm Hg) were significantly lower than that in control rats (61.4 +/- 13.4 mm Hg, P ˂ 0.05). The AUC values in rats receiving 3 mu g/kg (72.7 +/- 18.9 mm Hg x s) and 10 mu g/kg tamsulosin (23.5 +/- 6.1 mm Hg) and 1 mg/kg silodosin (23.9 +/- 8.0 mm Hg) were also lower than that of control rats (162.6 +/- 34.3 mm Hg, P ˂ 0.05). Conclusions. Telemetric ISVP assessment is reliable and feasible for investigating apomorphine-induced ejaculation in rats. Tamsulosin (3 mu g/kg and 10 mu g/kg) and silodosin 1 mg/kg decreased the ISVP during ejaculation.en_US
dc.description.sponsorshipThis study was supported by a grant from the Korean Health Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (HI14C0018).en_US
dc.language.isoen_USen_US
dc.publisherWILEY-BLACKWELLen_US
dc.subjectEjaculation Dysfunctionen_US
dc.subjectTelemetryen_US
dc.subjectTelemetry Monitoringen_US
dc.subjectApomorphineen_US
dc.subjectAPOMORPHINE-INDUCED ERECTIONen_US
dc.subjectPREMATURE-EJACULATIONen_US
dc.subjectINTRACAVERNOSAL PRESSUREen_US
dc.subjectNERVE-STIMULATIONen_US
dc.subjectPREVALENCEen_US
dc.subjectCOPULATIONen_US
dc.subjectMUSCLESen_US
dc.subjectBURDENen_US
dc.titleNew Methodology for Investigating Ejaculation Dysfunction: Measuring Intraluminal Seminal Vesicle Pressure in Rats with a Telemetric Deviceen_US
dc.typeArticleen_US
dc.relation.no11-
dc.relation.volume12-
dc.identifier.doi10.1111/jsm.13025-
dc.relation.page2134-2140-
dc.relation.journalJOURNAL OF SEXUAL MEDICINE-
dc.contributor.googleauthorSung, Hyun Hwan-
dc.contributor.googleauthorKim, Jung Jun-
dc.contributor.googleauthorHan, Deok Hyun-
dc.contributor.googleauthorKang, Su Jeong-
dc.contributor.googleauthorChae, Mee Ree-
dc.contributor.googleauthorKim, Chul Young-
dc.contributor.googleauthorPark, Jong Kwan-
dc.contributor.googleauthorLee, Sung Won-
dc.relation.code2015010625-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidchulykim-
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COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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