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Interleukin 17-expressing innate synovial cells drive K/BxN serum-induced arthritis

Title
Interleukin 17-expressing innate synovial cells drive K/BxN serum-induced arthritis
Author
윤지희
Keywords
IL-17; Synovial cells; Arthritis; Immune complex
Issue Date
2016-12
Publisher
대한면역학회
Citation
Immune Network, v. 16, NO 6, Page. 366-372
Abstract
K/BxN serum can induce arthritis in normal mice because of abundant autoantibodies that trigger an innate inflammatory response in joints. To determine whether IL-17 is involved in the pathogenesis of serum-induced arthritis, we injected wild-type and IL-17(-/-) mice with K/BxN serum and evaluated them for signs of arthritis. Unlike wild-type mice, IL-17(-/-) mice did not show any signs of arthritis. IL-17 was produced predominantly by CD3(-) CD4(-) gamma delta TCR- NK1.1(-) Sca1(int) Thy1(hi) cells residing in the inflamed synovial tissue. When synovial cells extracted from normal joints were stimulated with IL-23 or autoantibody-containing immune complexes, a substantial fraction of Sca1(int) Thy1(hi) cells produced IL-17. Thus, we have identified a novel population of IL-17-producing innate synovial cells that play a crucial role in the development of K/BxN serum-induced arthritis.
URI
https://synapse.koreamed.org/search.php?where=aview&id=10.4110/in.2016.16.6.366&code=0078IN&vmode=FULLhttps://repository.hanyang.ac.kr/handle/20.500.11754/101624
ISSN
1598-2629; 2092-6685
DOI
10.4110/in.2016.16.6.366
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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