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Effect of UV Photofunctionalization on Osseointegration in Aged Rats

Title
Effect of UV Photofunctionalization on Osseointegration in Aged Rats
Author
박원희
Keywords
dental implant; UV light; surface conditioning; titanium; old age
Issue Date
2016-12
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Citation
IMPLANT DENTISTRY, v. 25, Issue 6, Page. 744-750
Abstract
Objectives: This study evaluated the effect of photofunctionalization on osseointegration under the biologically adverse conditions of aging. Materials: First of all, bone marrow–derived osteoblastic cells from young (8 weeks old) and aged (15 months old) rats were biologically characterized. Then, the osteoblasts from aged rats were seeded on titanium discs with and without photofunctionalization, and assessed for initial cell attachment and osteoblastic functions. Titanium mini-implants, with and without photofunctionalization, were placed in the femur of aged rats, and the strength of osseointegration was measured at week 2 of healing. Periimplant tissue was examined morphologically and chemically using scanning electron microscopy and energy dispersive x-ray spectroscopy, respectively. Results: Cells from the aged rats showed substantially reduced biological capabilities compared with those derived from young rats. The cells from aged rats showed significantly increased cell attachment and the expression of osteoblastic function on photofunctionalized titanium than on untreated titanium. In addition, the strength of osseointegration was increased by 40% in aged rats carrying the photofunctionalized implants. Robust bone formation was observed around the photofunctionalized implants with strong elemental peaks of calcium and phosphorus, whereas the tissue around untreated implants showed weaker calcium and phosphate signals than titanium ones. Conclusion: These in vivo and in vitro results corroboratively demonstrate that photofunctionalization is effective for enhancing osseointegration in aged rats.
URI
https://oce.ovid.com/article/00008505-201612000-00008/HTMLhttps://repository.hanyang.ac.kr/handle/20.500.11754/101572
ISSN
1056-6163
DOI
10.1097/ID.0000000000000459
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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