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dc.contributor.author김동욱-
dc.date.accessioned2019-04-03T07:24:53Z-
dc.date.available2019-04-03T07:24:53Z-
dc.date.issued2015-08-
dc.identifier.citationTRENDS IN MICROBIOLOGY, v. 23, No. 8, Page. 479-489en_US
dc.identifier.issn0966-842X-
dc.identifier.issn1878-4380-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0966842X15000773-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/101432-
dc.description.abstractThe analysis of the whole-genome sequences of Vibrio cholerae strains from previous and current cholera pandemics has demonstrated that genomic changes and alterations in phage CTX (particularly in the gene encoding the B subunit of cholera toxin) were major features in the evolution of V. cholerae. Recent studies have revealed the genetic mechanisms in these bacteria by which new variants of V. cholerae are generated from type-specific strains; these mechanisms suggest that certain strains are selected by environmental or human factors over time. By understanding the mechanisms and driving forces of historical and current changes in the V. cholerae population, it would be possible to predict the direction of such changes and the evolution of new variants; this has implications for the battle against cholera.en_US
dc.description.sponsorshipThis work was supported by grant 2012R1A2A2A01009741 from the National Research Foundation (NRF) of Korea.en_US
dc.language.isoen_USen_US
dc.publisherELSEVIER SCI LTDen_US
dc.subjectVibrio choleraeen_US
dc.subjectcholeraen_US
dc.subjectcholera toxinen_US
dc.subjectphage CTXen_US
dc.subjectEL-TOR STRAINSen_US
dc.subjectCLASSICAL CTX PROPHAGEen_US
dc.subjectTANDEM-REPEAT ANALYSISen_US
dc.subjectTOXIN-Ben_US
dc.subjectVARIANTen_US
dc.subjectBIOTYPEen_US
dc.subjectBANGLADESHen_US
dc.subjectEMERGENCEen_US
dc.subjectOUTBREAKen_US
dc.subjectINDIAen_US
dc.titleWhole-genome sequence comparisons reveal the evolution of Vibrio cholerae O1en_US
dc.typeArticleen_US
dc.relation.no8-
dc.relation.volume23-
dc.identifier.doi10.1016/j.tim.2015.03.010-
dc.relation.page479-489-
dc.relation.journalTRENDS IN MICROBIOLOGY-
dc.contributor.googleauthorKim, Eun Jin-
dc.contributor.googleauthorLee, Chan Hee-
dc.contributor.googleauthorNair, G. Balakrish-
dc.contributor.googleauthorKim, Dong Wook-
dc.relation.code2015001986-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.piddongwook-
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COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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