Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 배상철 | - |
dc.date.accessioned | 2019-03-26T07:25:47Z | - |
dc.date.available | 2019-03-26T07:25:47Z | - |
dc.date.issued | 2016-11 | - |
dc.identifier.citation | RHEUMATOLOGY INTERNATIONAL, v. 36, NO 11, Page. 1591-1599 | en_US |
dc.identifier.issn | 0172-8172 | - |
dc.identifier.issn | 1437-160X | - |
dc.identifier.uri | https://link.springer.com/article/10.1007/s00296-016-3523-2 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/101209 | - |
dc.description.abstract | This study investigated whether the 5-aminoimidazole-4-carboxamide ribonucleotide transformylase gene (ATIC) 347 C/G polymorphism can predict the response to or toxicity of methotrexate (MTX) in patients with rheumatoid arthritis (RA). We conducted a meta-analysis of studies on the association between ATIC 347 C/G polymorphism and non-responsiveness to or toxicity of MTX in RA patients, using PUBMED, EMBASE, and COCHRANE. Nine comparative studies from 6 articles including 1056 RA patients met our inclusion criteria. This final group of studies comprised 5 studies on response to MTX and 4 on toxicity of MTX in RA patients in relation to the ATIC 347 C/G polymorphism status. Meta-analysis showed association between the ATIC 347 GG + GC genotype and non-response to MTX therapy (OR = 1.572, 95 % CI 1.146-2.156, p = 0.005). Stratification by ethnicity indicated significant association between the ATIC 347 GG + GC genotype and non-response to MTX in Caucasians (OR = 1.884, 95 % CI 1.236-2.873, p = 0.003), but not in Asian patients. Similarly, associations were noted for the ATIC 347 C/G polymorphism through analysis using recessive and overdominant models. Meta-analysis revealed association between the ATIC 347 GG + GC genotype and MTX toxicity (OR = 1.454 95 % CI 1.034-2.044, p = 0.032). Stratification by ethnicity indicated significant association between the ATIC 347 GG + GC genotype and MTX toxicity in Caucasians (OR = 1.741, 95 % CI 1.080-2.806, p = 0.023), but not in Asian patients. The ATIC 347 C/G polymorphism may be associated with non-responsiveness to and or toxicity of MTX in Caucasian RA patients. | en_US |
dc.description.sponsorship | This study was supported in part by a grant of the Korea Healthcare technology R&D Project, Ministry for Health and Welfare, Republic of Korea (HI15C2958). | en_US |
dc.language.iso | en | en_US |
dc.publisher | SPRINGER HEIDELBERG | en_US |
dc.subject | Rheumatoid arthritis | en_US |
dc.subject | ATIC | en_US |
dc.subject | Polymorphism | en_US |
dc.subject | Meta-analysis | en_US |
dc.title | Association of the ATIC 347 C/G polymorphism with responsiveness to and toxicity of methotrexate in rheumatoid arthritis: a meta-analysis | en_US |
dc.type | Article | en_US |
dc.relation.no | 11 | - |
dc.relation.volume | 36 | - |
dc.identifier.doi | 10.1007/s00296-016-3523-2 | - |
dc.relation.page | 1591-1599 | - |
dc.relation.journal | RHEUMATOLOGY INTERNATIONAL | - |
dc.contributor.googleauthor | Lee, Young Ho | - |
dc.contributor.googleauthor | Bae, Sang-Cheol | - |
dc.relation.code | 2016003713 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | scbae | - |
dc.identifier.orcid | http://orcid.org/0000-0003-4658-1093 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.