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Impact of malignancy on Clostridium difficile infection

Title
Impact of malignancy on Clostridium difficile infection
Author
정민성
Keywords
ADULT ONCOLOGY PATIENTS; RISK-FACTORS; HEALTH-CARE; CLINICAL CHARACTERISTICS; CANCER-PATIENTS; EPIDEMIOLOGY; DIARRHEA; DISEASE; CHEMOTHERAPY; BI/NAP1/027
Issue Date
2016-11
Publisher
SPRINGER
Citation
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, v. 35, Issue 11,Page. 1771-1776
Abstract
Purpose The purpose of this study was to investigate the impact of malignancy and chemotherapy on the clinical and microbiological characteristics of Clostridium difficile infections (CDI). Methods CDI patients with a history of malignancy within 5 years were defined as the cancer group. The characteristics of the patients were compared according to the presence of malignancy. Results Of 580 patients with CDI, 159 (27.4 %) belonged to the cancer group and 421 (72.6 %) to the non-cancer group. More of the patients in the cancer group than those in the non-cancer group had been hospitalized within the prior 2 months (P < 0.001). Leukocytosis was more common in the non-cancer group (P = 0.034), while infection by PCR ribotype 017 strains was more common in the cancer group, with marginal significance (P = 0.07). Recurrence was more frequent in the cancer group (20.4 % vs. 9.5 %, P =0.005) and cancer was an independent risk factor for recurrence of CDI (OR = 2.66, 95 % CI 1.34-5.29, P =0.005). Age also contributed to the recurrence of CDI (OR = 1.03, 95 % CI 1.00-1.06, P =0.026). Conclusions Malignancy and age are independent risk factors for recurrence of CDI. Cancer patients require careful observation for recurrence after treatment of CDI.
URI
https://link.springer.com/article/10.1007%2Fs10096-016-2725-6https://repository.hanyang.ac.kr/handle/20.500.11754/101188
ISSN
0934-9723; 1435-4373
DOI
10.1007/s10096-016-2725-6
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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