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dc.contributor.author유혜현-
dc.date.accessioned2019-03-19T00:41:04Z-
dc.date.available2019-03-19T00:41:04Z-
dc.date.issued2015-06-
dc.identifier.citationJOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v. 63, No. 22, Page. 5410-5416en_US
dc.identifier.issn0021-8561-
dc.identifier.issn1520-5118-
dc.identifier.urihttp://pubs.acs.org/doi/abs/10.1021/acs.jafc.5b01724-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/100964-
dc.description.abstractRhus verniciflua (Toxicodendron vernicifluum) is a medicinal tree popularly used in Asian countries such as China, Japan, and Korea as a food additive or herbal medicine because of its beneficial effects. R. verniciflua extract (RVE) contains diverse phenolic compounds, such as flavonoids, as its major biological active constituents. In this study, the pharmacokinetic profiles of eight phenolic compounds were investigated following oral administration of RVE to rats. The eight phenolic compounds were 2,4-dihydroxybenzoic acid, 3,4-dihydroxybenzoic acid, fisetin, fustin, butin, sulfuretin, taxifolin, and garbanzol. The plasma concentrations of the eight compounds were determined by using a liquid chromatography-triple-quadrupole mass spectrometer before and after treatment with beta-glucuronidase. When 1.5 g/kg RVE was administered, the eight compounds were all detected in plasma, mainly as conjugated forms. These pharmacokinetic data would be useful for understanding the pharmacological effects of RVE.en_US
dc.description.sponsorshipThis research was supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (NRF-2014R1A1A1A0S002840).en_US
dc.language.isoen_USen_US
dc.publisherAMER CHEMICAL SOCen_US
dc.subjectbioanalytical methoden_US
dc.subjectpharmacokineticsen_US
dc.subjectphenolic compoundsen_US
dc.subjectRhus verniciflua Stokesen_US
dc.subjectVERNICIFLUA STOKES EXTRACTen_US
dc.subjectHUMAN LYMPHOMA-CELLSen_US
dc.subjectANTIOXIDANT ACTIVITYen_US
dc.subjectIN-VIVOen_US
dc.subjectFLAVONOIDSen_US
dc.subjectSULFURETINen_US
dc.subjectAPOPTOSISen_US
dc.subjectINFLAMMATIONen_US
dc.subjectMACROPHAGESen_US
dc.subjectGROWTHen_US
dc.titlePharmacokinetic Profile of Eight Phenolic Compounds and Their Conjugated Metabolites after Oral Administration of Rhus vemiciflua Extracts in Ratsen_US
dc.typeArticleen_US
dc.relation.no22-
dc.relation.volume63-
dc.identifier.doi10.1021/acs.jafc.5b01724-
dc.relation.page5410-5416-
dc.relation.journalJOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY-
dc.contributor.googleauthorJin, MJ-
dc.contributor.googleauthorKim, IS-
dc.contributor.googleauthorPark, JS-
dc.contributor.googleauthorDong, MS-
dc.contributor.googleauthorNa, CS-
dc.contributor.googleauthorYoo, HH-
dc.relation.code2015002248-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidyoohh-
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COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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