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Pharmacokinetic Profile of Eight Phenolic Compounds and Their Conjugated Metabolites after Oral Administration of Rhus vemiciflua Extracts in Rats

Title
Pharmacokinetic Profile of Eight Phenolic Compounds and Their Conjugated Metabolites after Oral Administration of Rhus vemiciflua Extracts in Rats
Author
유혜현
Keywords
bioanalytical method; pharmacokinetics; phenolic compounds; Rhus verniciflua Stokes; VERNICIFLUA STOKES EXTRACT; HUMAN LYMPHOMA-CELLS; ANTIOXIDANT ACTIVITY; IN-VIVO; FLAVONOIDS; SULFURETIN; APOPTOSIS; INFLAMMATION; MACROPHAGES; GROWTH
Issue Date
2015-06
Publisher
AMER CHEMICAL SOC
Citation
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v. 63, No. 22, Page. 5410-5416
Abstract
Rhus verniciflua (Toxicodendron vernicifluum) is a medicinal tree popularly used in Asian countries such as China, Japan, and Korea as a food additive or herbal medicine because of its beneficial effects. R. verniciflua extract (RVE) contains diverse phenolic compounds, such as flavonoids, as its major biological active constituents. In this study, the pharmacokinetic profiles of eight phenolic compounds were investigated following oral administration of RVE to rats. The eight phenolic compounds were 2,4-dihydroxybenzoic acid, 3,4-dihydroxybenzoic acid, fisetin, fustin, butin, sulfuretin, taxifolin, and garbanzol. The plasma concentrations of the eight compounds were determined by using a liquid chromatography-triple-quadrupole mass spectrometer before and after treatment with beta-glucuronidase. When 1.5 g/kg RVE was administered, the eight compounds were all detected in plasma, mainly as conjugated forms. These pharmacokinetic data would be useful for understanding the pharmacological effects of RVE.
URI
http://pubs.acs.org/doi/abs/10.1021/acs.jafc.5b01724https://repository.hanyang.ac.kr/handle/20.500.11754/100964
ISSN
0021-8561; 1520-5118
DOI
10.1021/acs.jafc.5b01724
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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