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Analysis of Nociceptive Information Encoded in the Temporal Discharge Patterns of Cutaneous C-Fibers

Title
Analysis of Nociceptive Information Encoded in the Temporal Discharge Patterns of Cutaneous C-Fibers
Author
장동표
Keywords
temporal decoding; temporal encoding; spike train analysis; discharge pattern; nociception
Issue Date
2016-11
Publisher
FRONTIERS MEDIA S.A.
Citation
FRONTIERS IN COMPUTATIONAL NEUROSCIENCE, v.10, Page. 1-12
Abstract
The generation of pain signals from primary afferent neurons is explained by a labeled-line code. However, this notion cannot apply in a simple way to cutaneous C-fibers, which carry signals from a variety of receptors that respond to various stimuli including agonist chemicals. To represent the discharge patterns of C-fibers according to different agonist chemicals, we have developed a quantitative approach using three consecutive spikes. By using this method, the generation of pain in response to chemical stimuli is shown to be dependent on the temporal aspect of the spike trains. Furthermore, under pathological conditions, gamma-aminobutyric acid resulted in pain behavior without change of spike number but with an altered discharge pattern. Our results suggest that information about the agonist chemicals may be encoded in specific temporal patterns of signals in C-fibers, and nociceptive sensation may be influenced by the extent of temporal summation originating from the temporal patterns.
URI
https://www.frontiersin.org/articles/10.3389/fncom.2016.00118/fullhttps://repository.hanyang.ac.kr/handle/20.500.11754/100641
ISSN
1662-5188
DOI
https://doi.org/10.3389/fncom.2016.00118
Appears in Collections:
GRADUATE SCHOOL OF BIOMEDICAL SCIENCE AND ENGINEERING[S](의생명공학전문대학원) > ETC
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