116 0

Synthesis and optimization of ceftriaxone-loaded solid lipid nanocarriers

Title
Synthesis and optimization of ceftriaxone-loaded solid lipid nanocarriers
Author
김기현
Keywords
Ceftriaxone sodium; Solid lipid nanoparticles; Emulsification; Antibacterial; Nanoformulation
Issue Date
2016-10
Publisher
ELSEVIER IRELAND LTD
Citation
CHEMISTRY AND PHYSICS OF LIPIDS, v. 200, Page. 126-132
Abstract
The use of nanocarriers to enhance drug delivery efficacy has been increasing in the healthcare field due to their tunable surface properties. In this study, ceftriaxone-loaded solid lipid nanoparticles (CL-SLNPs) were synthesized using a water-in-oil-in-water (w/o/w) type double emulsification method. The formulation was optimized using response surface methodology (RSM) and was characterized using transmission electron microscopy (TEM), photon correlation spectroscopy (PCS), and UV vis and Fourier transform infrared (FTIR) spectroscopy. The CL-SLNPs were of spherical shape, 15-20 nm in size, and retained the properties of the drug or other constituents/ingredients after loading. The prepared nanoformulation offered sustained drug release after 24 h, while ceftriaxone sodium followed a burst release. Antibacterial activity of the nanoformulation was evaluated against different gram-positive and gram-negative bacterial strains. The minimum inhibitory concentration of CL-SLNPs against Pseudomonas aeruginosa was determined as 31 mu g/mL. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
URI
https://www.sciencedirect.com/science/article/pii/S0009308416301189?via%3Dihubhttps://repository.hanyang.ac.kr/handle/20.500.11754/100590
ISSN
0009-3084; 1873-2941
DOI
10.1016/j.chemphyslip.2016.09.002
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > CIVIL AND ENVIRONMENTAL ENGINEERING(건설환경공학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE