102 0

Subacute inhalation toxicity study of synthetic amorphous silica nanoparticles in Sprague-Dawley rats

Title
Subacute inhalation toxicity study of synthetic amorphous silica nanoparticles in Sprague-Dawley rats
Author
안강호
Keywords
Amorphous silica; inhalation toxicity; subacute; nanosilica
Issue Date
2017-01
Publisher
TAYLOR & FRANCIS LTD
Citation
INHALATION TOXICOLOGY, v. 29, No. 12-14, Page. 567-576
Abstract
Synthetic amorphous silica nanoparticles (SiNPs) are one of the most applied nanomaterials and are widely used in a broad variety of industrial and biomedical fields. However, no recent long-term inhalation studies evaluating the toxicity of SiNPs are available and results of acute studies are limited. Thus, we conducted a subacute inhalation toxicity study of SiNPs in Sprague-Dawley rats using a nose-only inhalation system. Rats were separated into four groups and target concentrations selected in this study were as follows: control (fresh air), low- (0.407 +/- 0.066mg/m(3)), middle- (1.439 +/- 0.177mg/m(3)) and high-concentration group (5.386 +/- 0.729mg/m(3)), respectively. The rats were exposed to SiNPs for four consecutive weeks (6hr/day, 5days/week) except for control group of rats which received filtered fresh air. After 28-days of inhalation exposure to SiNPs, rats were sacrificed after recovery periods of one, seven and 28days. Although there were minimal toxic changes such as temporary decrease of body weight after exposure, increased levels of red blood cells (RBCs) and hemoglobin (Hb) concentration, the lung histopathological findings and inflammatory markers in bronchoalveolar lavage (BAL) fluid including polymorphonuclear (PMN) leukocyte, lactate dehydrogenase (LDH), albumin and protein did not show significant changes at any recovery period. The results of this study suggest that the subacute inhalation of SiNPs had no toxic effects on the lung of rats at the concentrations and selected time points used in this study.
URI
https://www.tandfonline.com/doi/abs/10.1080/08958378.2018.1426661https://repository.hanyang.ac.kr/handle/20.500.11754/100505
ISSN
1091-7691; 0895-8378
DOI
10.1080/08958378.2018.1426661
Appears in Collections:
COLLEGE OF ENGINEERING SCIENCES[E](공학대학) > MECHANICAL ENGINEERING(기계공학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE