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dc.contributor.author배상철-
dc.date.accessioned2019-03-05T01:11:14Z-
dc.date.available2019-03-05T01:11:14Z-
dc.date.issued2016-10-
dc.identifier.citationCELLULAR AND MOLECULAR BIOLOGY, v. 62, NO. 12, Page. 84-90en_US
dc.identifier.issn0145-5680-
dc.identifier.issn1165-158X-
dc.identifier.urihttps://www.cellmolbiol.org/index.php/CMB/article/view/1176-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/100461-
dc.description.abstractThe aim of this study was to determine whether intercellular adhesion molecule-1 (ICAM-1) polymorphisms are associated with susceptibility to vasculitis or rheumatoid arthritis (RA). Meta-analyses were performed to assess the associations between K469E and G241R polymorphisms of ICAM-1 and vasculitis or RA. A total of 12 studies on 1,368 patients and 1,922 controls, which comprised 8 vasculitis studies and 4 RA studies, were included in the meta-analysis. We found no significant association between vasculitis and K469E E allele among the various subjects (OR = 1.238, 95% CI = 0.9781-1.566, p = 0.076). However, an association between vasculitis and K469E polymorphism was observed under homozygote contrast (OR = 1.443, 95% CI = 1.084-1.920, p = 0.012). Stratification by ethnicity and vasculitis type showed no association between vasculitis and 1 K469E polymorphism under heterozygote contrast. In addition, the meta-analysis revealed a significant association between the ICAM-1 G241R R allele and Behcet's disease (BD) (OR = 3.261, 95% CI = 1.653-6.434, p = 0.001), but not giant cell arteritis. Moreover, the meta-analysis indicated an association between RA and the R allele and RR+RG genotype of the ICAM-1 G241R polymorphism (OR = 2.014, 95% CI = 1.215-3.339, p = 0.007; OR = 2.394, 95% CI = 1.354-4.235, p = 0.003). This meta-analysis suggests that the K469E polymorphism is associated with susceptibility to vasculitis, and that the G241R polymorphism is associated with susceptibility to BD and RA.en_US
dc.description.sponsorshipThis study was supported in part by a grant of the Korea Healthcare technology R&D Project, Ministry for Health and Welfare, Republic of Korea (HI15C2958).en_US
dc.language.isoenen_US
dc.publisherC M B ASSOCen_US
dc.subjectVasculitisen_US
dc.subjectrheumatoid arthritisen_US
dc.subjectICAM-1en_US
dc.subjectpolymorphismen_US
dc.subjectmeta-analysisen_US
dc.titleIntercellular adhesion molecule-1 polymorphisms, K469E and G261R and susceptibility to vasculitis and rheumatoid arthritis: a meta-analysisen_US
dc.typeArticleen_US
dc.relation.no12-
dc.relation.volume62-
dc.relation.page84-90-
dc.relation.journalCELLULAR AND MOLECULAR BIOLOGY-
dc.contributor.googleauthorLee, Y. H.-
dc.contributor.googleauthorBae, S-C.-
dc.relation.code2016001108-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidscbae-
dc.identifier.orcidhttp://orcid.org/0000-0003-4658-1093-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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