Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 배상철 | - |
dc.date.accessioned | 2019-03-05T01:11:14Z | - |
dc.date.available | 2019-03-05T01:11:14Z | - |
dc.date.issued | 2016-10 | - |
dc.identifier.citation | CELLULAR AND MOLECULAR BIOLOGY, v. 62, NO. 12, Page. 84-90 | en_US |
dc.identifier.issn | 0145-5680 | - |
dc.identifier.issn | 1165-158X | - |
dc.identifier.uri | https://www.cellmolbiol.org/index.php/CMB/article/view/1176 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/100461 | - |
dc.description.abstract | The aim of this study was to determine whether intercellular adhesion molecule-1 (ICAM-1) polymorphisms are associated with susceptibility to vasculitis or rheumatoid arthritis (RA). Meta-analyses were performed to assess the associations between K469E and G241R polymorphisms of ICAM-1 and vasculitis or RA. A total of 12 studies on 1,368 patients and 1,922 controls, which comprised 8 vasculitis studies and 4 RA studies, were included in the meta-analysis. We found no significant association between vasculitis and K469E E allele among the various subjects (OR = 1.238, 95% CI = 0.9781-1.566, p = 0.076). However, an association between vasculitis and K469E polymorphism was observed under homozygote contrast (OR = 1.443, 95% CI = 1.084-1.920, p = 0.012). Stratification by ethnicity and vasculitis type showed no association between vasculitis and 1 K469E polymorphism under heterozygote contrast. In addition, the meta-analysis revealed a significant association between the ICAM-1 G241R R allele and Behcet's disease (BD) (OR = 3.261, 95% CI = 1.653-6.434, p = 0.001), but not giant cell arteritis. Moreover, the meta-analysis indicated an association between RA and the R allele and RR+RG genotype of the ICAM-1 G241R polymorphism (OR = 2.014, 95% CI = 1.215-3.339, p = 0.007; OR = 2.394, 95% CI = 1.354-4.235, p = 0.003). This meta-analysis suggests that the K469E polymorphism is associated with susceptibility to vasculitis, and that the G241R polymorphism is associated with susceptibility to BD and RA. | en_US |
dc.description.sponsorship | This study was supported in part by a grant of the Korea Healthcare technology R&D Project, Ministry for Health and Welfare, Republic of Korea (HI15C2958). | en_US |
dc.language.iso | en | en_US |
dc.publisher | C M B ASSOC | en_US |
dc.subject | Vasculitis | en_US |
dc.subject | rheumatoid arthritis | en_US |
dc.subject | ICAM-1 | en_US |
dc.subject | polymorphism | en_US |
dc.subject | meta-analysis | en_US |
dc.title | Intercellular adhesion molecule-1 polymorphisms, K469E and G261R and susceptibility to vasculitis and rheumatoid arthritis: a meta-analysis | en_US |
dc.type | Article | en_US |
dc.relation.no | 12 | - |
dc.relation.volume | 62 | - |
dc.relation.page | 84-90 | - |
dc.relation.journal | CELLULAR AND MOLECULAR BIOLOGY | - |
dc.contributor.googleauthor | Lee, Y. H. | - |
dc.contributor.googleauthor | Bae, S-C. | - |
dc.relation.code | 2016001108 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | scbae | - |
dc.identifier.orcid | http://orcid.org/0000-0003-4658-1093 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.