TY - JOUR AU - 이수재 DA - 2015/10 PY - 2015 UR - http://www.nature.com/articles/srep15809 UR - http://hdl.handle.net/20.500.11754/27964 AB - Recently low dose irradiation has gained attention in the field of radiotherapy. For lack of understanding of the molecular consequences of low dose irradiation, there is much doubt concerning its risks on human beings. In this article, we report that low dose irradiation is capable of blocking the oncogenic KRAS-induced malignant transformation. To address this hypothesis, we showed that low dose irradiation, at doses of 0.1 Gray (Gy); predominantly provide defensive response against oncogenic KRAS - induced malignant transformation in human cells through the induction of antioxidants without causing cell death and acts as a critical regulator for the attenuation of reactive oxygen species (ROS). Importantly, we elucidated that knockdown of antioxidants significantly enhanced ROS generation, invasive and migratory properties and abnormal acini formation in KRAS transformed normal as well as cancer cells. Taken together, this study demonstrates that low dose irradiation reduces the KRAS induced malignant cellular transformation through diminution of ROS. This interesting phenomenon illuminates the beneficial effects of low dose irradiation, suggesting one of contributory mechanisms for reducing the oncogene induced carcinogenesis that intensify the potential use of low dose irradiation as a standard regimen. PB - NATURE PUBLISHING GROUP KW - CANCER KW - IRRADIATION KW - HYPERSENSITIVITY KW - PROLIFERATION KW - RADIOTHERAPY KW - INDUCTION KW - IMMUNITY KW - HORMESIS KW - THERAPY KW - REPAIR TI - Beneficial effects of low dose radiation in response to the oncogenic KRAS induced cellular transformation VL - 5 DO - 10.1038/srep15809 T2 - SCIENTIFIC REPORTS ER -