TY - JOUR AU - 배상철 DA - 2019/10 PY - 2019 UR - https://link.springer.com/article/10.1007%2Fs00393-018-0537-z UR - https://repository.hanyang.ac.kr/handle/20.500.11754/154632 AB - Objective. To examine whether alcohol intake is causally associated with rheumatoid arthritis (RA). Methods. We performed a two-sample Mendelian randomization (MR) analysis using the inverse-variance weighted (IVW), weighted median, and MR-Egger regression methods. We used the publicly available summary statistics of alcohol intake frequency from the UK Biobank genome-wide association studies (GWASs; n = 336,965) as the exposure and a GWAS meta-analysis of 5539 autoantibody-positive RA patients and 20,169 controls as the outcome. Results. We selected 24 single nucleotide polymorphisms (SNPs) associated with alcohol intake frequency at genome-wide significance as instrumental variables (IVs) to improve inference, 16 of which were inversely associated with RA. The IVW method showed no evidence of a causal association between alcohol intake and RA (beta = 0.218, SE = 0.213, p = 0.306). The MR-Egger regression revealed that directional pleiotropy was unlikely to bias the result (intercept = 0.027, p = 0.292). The MR-Egger analysis and the weighted median approach showed no causal association between alcohol intake and RA (beta = -0.778, SE = 0.947, p = 0.420 and beta = -0.286, SE = 0.302, p = 0.344, respectively). Cochran's Q test did not indicate heterogeneity between IV estimates based on the individual variants, and results from a "leave-one-out" analysis demonstrated that no single SNP was driving the IVW point estimate. Conclusion. The MR analysis does not support a causal inverse association between alcohol intake and RA occurrence. PB - SPRINGER HEIDELBERG KW - Alcohol intake KW - Rheumatoid arthritis KW - Mendelian randomization KW - Genetic predisposition to disease KW - Genome-wide association study TI - Alcohol intake and risk of rheumatoid arthritis: a Mendelian randomization study IS - 8 VL - 78 DO - 10.1007/s00393-018-0537-z T2 - ZEITSCHRIFT FUR RHEUMATOLOGIE ER -