TY - JOUR AU - 윤소원 DA - 2016/12 PY - 2016 UR - https://pubs.acs.org/doi/10.1021/acs.orglett.6b03151 UR - https://repository.hanyang.ac.kr/handle/20.500.11754/102319 AB - A simple and facile one-pot reaction has been developed to afford a diverse range of N,N'-disubstituted benzimidazolones and imidazopyridinones containing two differently substituted N atoms. A cooperative Pd(II)/Ag(I) system promotes the sequential addition/intramolecular C-H amidation reaction of (hetero)aromatic amines and isocyanates, leading to the formation of two C-N bonds. A mechanism involving radical intermediates generated by single-electron transfer (SET) in the presence of a Ag2CO3 oxidant and Pd(OAc)(2) Lewis acid is proposed. This protocol offers an operationally easy, simple, and robust approach with the use of readily available starting materials, good functional group tolerance, and high efficiency. PB - AMER CHEMICAL SOC KW - CATALYZED OXIDATIVE CYCLIZATION KW - C-H AMINATION KW - N-SUBSTITUTED 1,3-DIHYDROBENZIMIDAZOL-2-ONES KW - INTRAMOLECULAR CYCLIZATION KW - CARBOXYLIC-ACIDS KW - CROSS-COUPLING/CYCLIZATION KW - REGIOSELECTIVE SYNTHESIS KW - ANTISECRETORY ACTIVITY KW - MEDIATED REACTIONS KW - BENZIMIDAZOLONES TI - Pd(II)/Ag(I)-Promoted One-Pot Synthesis of Cyclic Ureas from (Hetero)Aromatic Amines and Isocyanates IS - 23 VL - 18 DO - 10.1021/acs.orglett.6b03151 T2 - ORGANIC LETTERS ER -