이종민
2017-08-09T01:53:31Z
2017-08-09T01:53:31Z
2015-10
NEUROIMAGE, v. 119, Page. 296-304
1053-8119
1095-9572
http://www.sciencedirect.com/science/article/pii/S1053811915005820?via%3Dihub
http://hdl.handle.net/20.500.11754/28390
As an indicator of synchronous neural activity, resting-state functional networks are influenced by neuropathological and neurochemical changes in degenerative diseases. To further advance understanding about neurochemical and neuropathological basis for resting-state functional maps, we performed a comparative analysis of resting-state functional connectivity in patients with Parkinson's disease (PD) and drug induced parkinsonism (DIP). Resting-state neuroimaging data were analyzed with a seed-based approach to investigate striatocortical functional connectivity and cortical functional connectivity within the default mode network, executive control network, and the dorsal attention network. The striatal subregions were divided into the more or less affected sides in terms of dopamine transporter uptake. Compared with DIP, PD exhibited an increased cerebellar connectivity from the more affected side of the caudate and the less affected sides of the anterior and the posterior putamen. Additionally, PD showed increased functional connectivity in the anterior prefrontal areas from the more affected side of the anterior putamen and from the less affected side of the posterior putamen. However, PD exhibited decreased cortical functional connectivity from the posterior cingulate cortex in the left temporal area. Finally, DIP patients showed decreased cortical functional connectivity from the dorsolateral prefrontal cortex in frontal and parietal areas compared with PD patients. In summary, the present study demonstrates that PD patients exhibited a unique resting state functional connectivity that may be associated with PD-related pathological changes beyond the dopaminergic system, whereas DIP patients showed altered functional connectivity within executive control network. (C) 2015 Published by Elsevier Inc.
This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI14C0093).
en
ACADEMIC PRESS INC ELSEVIER SCIENCE
Resting-state functional connectivity
Parkinson's disease
Drug induced parkinsonism
Dopamine independent network
Nigrostriatal dopamine-independent resting-state functional networks in Parkinson's disease
Article
119
10.1016/j.neuroimage.2015.06.077
296-304
NEUROIMAGE
Ham, Jee Hyun
Cha, Jungho
Lee, Jae Jung
Baek, Gwang-Min
Sunwoo, Mun Kyung
Hong, Jin Yong
Shin, Na-Young
Sohn, Young Ho
Lee, Jong-Min
Lee, Phil Hyu
2015001993
S
COLLEGE OF ENGINEERING[S]
DIVISION OF ELECTRICAL AND BIOMEDICAL ENGINEERING
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