이수재
2016-05-25T07:38:10Z
2016-05-25T07:38:10Z
2015-01
CANCER SCIENCE, v. 106, NO 1, Page. 94-101
1347-9032
http://hdl.handle.net/20.500.11754/21349
http://onlinelibrary.wiley.com/doi/10.1111/cas.12562/full
Metastasis is a challenging clinical problem and the primary cause of death in breast cancer patients. However, there is no therapeutic agent against metastasis of breast cancer cells. Here we report that phloroglucinol, a natural phlorotannin component of brown algae suppresses metastatic ability of breast cancer cells. Treatment with phloroglucinol effectively inhibited mesenchymal phenotypes of basal type breast cancer cells through downregulation of SLUG without causing a cytotoxic effect. Importantly, phloroglucinol decreased SLUG through inhibition of PI3K/AKT and RAS/RAF-1/ERK signaling. In agreement with in vitro data, phloroglucinol was also effective against in vivo metastasis of breast cancer cells, drastically suppressing their metastatic ability to lungs, and extending the survival time of mice. Collectively, our findings demonstrate a novel anticancer activity of phloroglucinol against metastasis of breast cancer cells, implicating its clinical relevance.
This work was supported by the National Research Foundation (NRF) and Ministry of Science, ICT and Future Planning, Korean government, through its National Nuclear Technology Program (NRF-2012M2B2B1055639); and Converging Research Center Program Grant (2013K000283).
en
WILEY-BLACKWELL
phloroglucinol
cancer metastasis
basal type breast cancer cells
epithelial-mesenchymal transition
SLUG
Phloroglucinol suppresses metastatic ability of breast cancer cells by inhibition of epithelial-mesenchymal cell transition
Article
1
106
10.1111/cas.12562
94-101
CANCER SCIENCE
Kim, Rae-Kwon
Suh, Yongjoon
Yoo, Ki-Chun
Hwang, Eunji
Kim, Hyun-Jin
Kim, Min-Jung
Lee, Su-Jae
Kang, Ju-Seop
Cui, Yan-Hong
Lee, Young Yiul
2015001495
S
COLLEGE OF NATURAL SCIENCES[S]
DEPARTMENT OF LIFE SCIENCE
sj0420