윤소원
2019-12-10T07:46:43Z
2019-12-10T07:46:43Z
2018-12
ORGANIC LETTERS, v. 20, no. 24, page. 7869-7874
1523-7060
1523-7052
https://pubs.acs.org/doi/10.1021/acs.orglett.8b03409
https://repository.hanyang.ac.kr/handle/20.500.11754/120962
Regio- and stereoselective synthesis of (E)-3-arylmethyleneisoindolin-1-ones via Pd(II)/Cu(II)-catalyzed one pot C-C/C-N bond forming sequence between amides and styrenes is reported. This method provides facile and rapid access to a diverse range of such compounds using readily available starting materials under mild aerobic conditions with good functional group tolerance and high selectivity and efficiency. Further elaboration of the products obtained from this process enabled very short and efficient syntheses of aristolactam and indoloisoquinolinone alkaloids.
This paper is dedicated to Professor Yong Hae Kim on the occasion of his 80th birthday. This work was supported by both the Basic Science Research Program and Nano.Material Technology Department Program through the National Research Foundation of Korea (NRF) funded by the Korea government (MSIP) (Nos. 2012M3A7B4049644, 2014-011165, 2015R1A2A2A01002559, and 2018R1A2A2A05018392). We thank Dr. Ji-Eun Lee (Central Instrument Facility, Gyeongsang National University) for X-ray crystallographic analysis.
en_US
AMER CHEMICAL SOC
ONE-POT SYNTHESIS
C-H ACTIVATION
POSSESSING INHIBITORY-ACTIVITY
MIYAURA DOMINO REACTIONS
ALIPHATIC AMIDES
HIGHLY REGIO
INTRAMOLECULAR CYCLIZATION
REGIOSELECTIVE SYNTHESIS
OXIDATIVE OLEFINATION
CATALYZED ANNULATION
Pd(II)/Cu(II)-Catalyzed Regio- and Stereoselective Synthesis of (E)-3-Arylmethyleneisoindolin-1-ones Using Air as the Terminal Oxidant
Article
24
20
10.1021/acs.orglett.8b03409
7869-7874
ORGANIC LETTERS
Youn, So Won
Ko, Tae Yun
Kim, Young Ho
Kim, Yun Ah
2018001077
S
COLLEGE OF NATURAL SCIENCES[S]
DEPARTMENT OF CHEMISTRY
sowony73
P-2060-2015
http://orcid.org/0000-0002-2134-6487