임태호
2019-11-28T06:28:59Z
2019-11-28T06:28:59Z
2017-08
AMERICAN JOURNAL OF EMERGENCY MEDICINE, v. 35, no. 10, page. 1444-1450
0735-6757
1532-8171
https://www.ajemjournal.com/article/S0735-6757(17)30302-9/fulltext
https://repository.hanyang.ac.kr/handle/20.500.11754/115056
Purpose: Copeptin, the C-terminal portion of provasopressin, has emerged as a novel prognostic marker in neurocritical care, such as in traumatic brain injury (TBI). The aim of this study was to quantitatively assess the prognostic significance of initial plasma copeptin levels in the neurological outcome and mortality after traumatic brain injury. Materials and methods: Six relevant studies with data from 552 patients were included in this meta-analysis. Results: The plasma copeptin levels were found to be significantly higher in patients who died than in the survivors (standardized mean difference [SMD], 1.80). In the four studies reporting Glasgow outcome scale (GOS) data, patients with unfavorable outcomes had significantly higher copeptin levels than those with favorable outcomes (SMD, 1.62). The plasma copeptin level predicted mortality and unfavorable outcomes (AUC, 0.873; AUC, 0.876). Conclusions: The present meta-analysis suggests that early measurement of plasma copeptin levels can provide better prognostic information about the functional outcome and mortality in patients with TBI. (C) 2017 Elsevier Inc. All rights reserved.
en_US
W B SAUNDERS CO-ELSEVIER INC
Traumatic brain injury
Copeptin
Meta-analysis
Prognosis
Prognostic role of copeptin after traumatic brain injury: A systematic review and meta-analysis of observational studies
Article
10
35
10.1016/j.ajem.2017.04.038
1444-1450
AMERICAN JOURNAL OF EMERGENCY MEDICINE
Choi, Kyu-Sun
Cho, Youngsuk
Jang, Bo-Hyoung
Kim, Wonhee
Ahn, Chiwon
Lim, Tae Ho
Yi, Hyoung-Joong
2017009593
S
COLLEGE OF MEDICINE[S]
DEPARTMENT OF MEDICINE
erthim