KAUSHIKNEHA
2019-11-27T00:24:59Z
2019-11-27T00:24:59Z
2017-07
ONCOTARGET, v. 8, no. 36, page. 60188-60200
1949-2553
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=19028&path[]=60998
https://repository.hanyang.ac.kr/handle/20.500.11754/114892
The tumorigenic potentials of residual cancer stem-like cells within tumors represent limitations of current cancer therapies. Here, the authors describe the effects of synthesized flexible, ligated, supramolecular self-assembled chair type tetranuclear ruthenium (II) metallacycles (2-5) on glioblastoma and glioma stem like cells. These self-assemblies were observed to be selectively toxic to glioma cells and CD133-positive glioma stem like cells population. Of the self-assembled compounds tested, metallacycle 4 more efficiently induced glioma stem like cells death within a brain cancer cell population and simultaneously inhibited the formation of free-floating gliospheres by reducing the sphere size. Detailed cell death studies revealed that treatment with metallacycle 4 reduced mitochondrial membrane potentials (an indicator of apoptosis) of glioma stem like cells. These results shows the elimination of cancer stem-like cells using an appropriate ligand binding adaptor offers a potential means of developing metal-based compounds for the treatment of chemo-resistant tumors.
This work was supported by the Basic Science Research program through the National Research Foundation of Korea (2016R1A2B4007433 to K.W.C and 2014R1A1A2007828 to P.E.), and by the Priority Research Centers program (2009-0093818) through the NRF. We also acknowledge the financial assistance afforded by the Korean government (MSIP) (NRF-2010-0027963), (NRF-2016K1A4A3914113), (NRF-2015M2A2A7A01044998), (NRF-2016R1C1B2010851). This work is supported by research grant of Kwangwoon University in 2017.
en_US
IMPACT JOURNALS LLC
self-assembly
flexible ligand
arene-ruthenium
metallacycle
solid cancer
Flexible ligated ruthenium(II) self-assemblies sensitizes glioma tumor initiating cells in vitro
Article
10.18632/oncotarget.19028
10.18632/oncotarget.19028
60188-60200
ONCOTARGET
Elumalai, Palani
Kaushik, Neha
Kim, Dong Hwan
Kim, Hyunuk
Lee, Su Jae
Choi, Eun Ha
Chi, Ki-Whan
Kaushik, Nagendra Kumar
2017009424
S
RESEARCH INSTITUTE[S]
THE RESEARCH INSTITUTE FOR NATURAL SCIENCES
neha1987