공구
2019-04-19T00:22:25Z
2019-04-19T00:22:25Z
2016-12
CELLULAR AND MOLECULAR LIFE SCIENCES, v. 73, Issue 24, Page. 4643-4660
1420-682X
1420-9071
https://link.springer.com/article/10.1007%2Fs00018-016-2313-z
https://repository.hanyang.ac.kr/handle/20.500.11754/102344
The epithelial-mesenchymal transition (EMT) is a crucial developmental process by which epithelial cells undergo a mesenchymal phenotypic change. During EMT, epigenetic mechanisms including DNA methylation and histone modifications are involved in the regulation of EMT-related genes. The epigenetic gene silencing of the epithelial marker E-cadherin has been well characterized. In particular, three major transcriptional repressors of E-cadherin, Snail, ZEB, and Twist families, also known as EMT-inducing transcription factors (EMT-TFs), play a crucial role in this process by cooperating with multiple epigenetic modifiers. Furthermore, recent studies have identified the novel epigenetic modifiers that control the expression of EMT-TFs, and these modifiers have emerged as critical regulators of cancer development and as novel therapeutic targets for human cancer. In this review, the diverse functions of EMT-TFs in cancer progression, the cooperative mechanisms of EMT-TFs with epigenetic modifiers, and epigenetic regulatory roles for the expression of EMT-TFs will be discussed.
This work was supported by National Research Foundation of Korea (NRF) Grants funded by the Korean government (No. 2015R1A2A1A10052578).
en
SPRINGER BASEL AG
EMT
EMT transcription factor
Human cancer
Epigenetics
Chromatin
Histone modification
DNA methylation
Roles and epigenetic regulation of epithelial-mesenchymal transition and its transcription factors in cancer initiation and progression
Article
24
73
10.1007/s00018-016-2313-z
4643-4660
CELLULAR AND MOLECULAR LIFE SCIENCES
Lee, Jeong-Yeon
Kong, Gu
2016003406
S
COLLEGE OF MEDICINE[S]
DEPARTMENT OF MEDICINE
gkong