김도균
2019-05-23T02:01:39Z
2019-05-23T02:01:39Z
2018-12
ACS NANO, v. 12, No. 12, Page. 12380-12392
1936-0851
1936-086X
https://pubs.acs.org/doi/abs/10.1021/acsnano.8b06399
https://repository.hanyang.ac.kr/handle/20.500.11754/105793
Ferroptosis, an iron-based cell-death pathway, has recently attracted great attention owing to its effectiveness in killing cancer cells. Previous investigations focused on the development of iron-based nanomaterials to induce ferroptosis in cancer cells by the up-regulation of reactive oxygen species (ROS) generated by the well-known Fenton reaction. Herein, we report a ferroptosis-inducing agent based on arginine-rich manganese silicate nanobubbles (AMSNs) that possess highly efficient glutathione (GSH) depletion ability and thereby induce ferroptosis by the inactivation of glutathione-dependent peroxidases 4 (GPX4). The AMSNs were synthesized via a one-pot reaction with arginine (Arg) as the surface ligand for tumor homing. Subsequently, a significant tumor suppression effect can be achieved by GSH depletion-induced ferroptosis. Moreover, the degradation of AMSNs during the GSH depletion contributed to T-1-weighted magnetic resonance imaging (MRI) enhancement as well as on-demand chemotherapeutic drug release for synergistic cancer therapy. We anticipate that the GSH-depletion-induced ferroptosis strategy by using manganese-based nanomaterials would provide insights in designing nanomedicines for tumor-targeted theranostics.
We gratefully acknowledge the financial support provided by the National Key Research and Development Program of China (grant nos. 2016YFA0203600, 2016YFA0100900, and 2016YFA0201600), the National Natural Science Foundation of China (grants nos. 31822019, 51503180, 51611540345, 51703195, 81471739, 21777036, and 81430040), the "Thousand Talents Program" for Distinguished Young Scholars, the Fundamental Research Funds for the Central Universities (grant nos. 2018QNA7020 and 2017XZZX001-04), the Research Center Program for the Institute of Basic Science (grant no. IBS-R006-D1), and the Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology (grant no. CE140100036).
en_US
AMER CHEMICAL SOC
nanobubbles
glutathione
GPX4
ferroptosis
theranostics
Arginine-rich manganese silicate nanobubbles as a ferroptosis-inducing agent for tumor-targeted theranostics
Article
10.1021/acsnano.8b06399
ACS NANO
Wang, Shuaifei
Li, Fangyuan
Qiao, Ruirui
Hu, Xi
Liao, Honrei
Chen, Lumin
Wu, Jiahe
Wu, Haibin
Zhao, Meng
Kim, Dokyoon
Liu, Jianan
Chen, Rui
Ma, Xibo
Sun, Jihong
Davis, Thomas P.
Chen, Chunying
Tian, Jie
Hyeon, Taeghwan
Ling, Daishun
2018000602
E
COLLEGE OF ENGINEERING SCIENCES[E]
DEPARTMENT OF BIONANO ENGINEERING
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