문지용
2019-02-14T02:39:43Z
2019-02-14T02:39:43Z
2016-10
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, v. 240, NO. 2, Page. 131-139
0040-8727
1349-3329
https://www.jstage.jst.go.jp/article/tjem/240/2/240_131/_article
https://repository.hanyang.ac.kr/handle/20.500.11754/98978
Exacerbations of chronic obstructive pulmonary disease (COPD) lead to high morbidity and mortality. Respiratory virus infection is considered as one of the important causes of COPD exacerbations. The aim of this study was to assess the prevalence of respiratory virus infection in COPD exacerbations and to find the factors associated with susceptibility to viral infections. Furthermore, we tried to examine if COPD exacerbations caused by viral infections have more severe clinical outcomes in comparison with those with non-viral causes. We enrolled the patients with acute exacerbations of COPD who were hospitalized in a university hospital, over a 2-year period. Nasopharyngeal swabs were taken and viruses were identified by multiplex polymerase chain reaction. A total of 278 episodes of COPD exacerbations were recorded in 213 patients with COPD (number of females = 73). Among the COPD exacerbations, viral infection was detected in 78 episodes (28.1%) from 67 subjects. The most common virus was rhinovirus (38.8%), followed by respiratory syncytial virus, coronavirus, influenza A, parainfluenza, adenovirus and metapneumovirus. In multivariate regression analysis adjusting for sex, age, BMI, lung function and history of exacerbations, female subjects were found to be significantly associated with viral infections in COPD exacerbations (Odds ratio 2.58, 95%CI 1.25-5.31, P = 0.010). The severity of COPD exacerbations were not different between positive and negative viral detections. In conclusion, the prevalence of viral infection was 28.1% in the hospitalized patients with COPD exacerbations. Moreover, female subjects are at significantly higher risk for viral infections in COPD exacerbations.
This work was supported by the research fund of Hanyang University (HY-2011-MC).
en
TOHOKU UNIV MEDICAL PRESS
chronic obstructive pulmonary disease
exacerbation
multiplex polymerase chain reaction
respiratory virus
infection
Prevalence and Risk Factors of Respiratory Viral Infections in Exacerbations of Chronic Obstructive Pulmonary Disease
Article
2
240
10.1620/tjem.240.131
131-139
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
Kwak, Hyun Jung
Park, Dong Won
Kim, Jee Eun
Park, Min Kyung
Koo, Gun Woo
Park, Tai Sun
Moon, Ji-Yong
Kim, Tae Hyung
Sohn, Jang Won
Yoon, Ho Joo
2016000943
S
COLLEGE OF MEDICINE[S]
DEPARTMENT OF MEDICINE
moonji