Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 조천규 | - |
dc.contributor.author | 김정화 | - |
dc.date.accessioned | 2019-02-28T03:04:23Z | - |
dc.date.available | 2019-02-28T03:04:23Z | - |
dc.date.issued | 2019-02 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/99862 | - |
dc.identifier.uri | http://hanyang.dcollection.net/common/orgView/200000434729 | en_US |
dc.description.abstract | We have previously reported a synthesis of ene-hydrazide from enol triflate and a subsequent indolization reaction as a new entry to the regioselective Fischer indole synthesis.1 In this process, a base-catalyzed intramolecular aza-Michael reaction, in situ trapping of the resulting enolate, and subsequent C-N coupling with phenyl hydrazide afforded the key ene-hydrazides. This new synthetic strategy has been successfully applied to the total synthesis of (+)-aspidospermidine and (-)-tabersonine.2 Toward further development of our strategy, we have envisaged a new synthetic route to (±)-tubifolidine. Buchwald-Hartwig type amination and regioselective Fischer indolization under Lewis acidic conditions would selectively afford desired indole 2. Presented herein is the progress toward the syntheses of (±)-tubifolidine.; 우리 연구실에서는 enol triflate로 부터 ene-hydrazide를 만들어 indolization 반응 을 통하여 위치 선택성을 가지고 있는 인돌 화합물 합성을 연구해 왔다. 이 방법을 사용하여 (±)-tubifolidine 이라는 천연물 합성을 목표로 하였고 중요 스텝으로는 aza-Michael addition과 triflation을 통하여 만들어진 enol triflate에 Buchwald Hartwig type amination을 통하여 ene-hydrazide 형태의 화합물 합성을 계획하였고 그 후 Lewis 산 존재 하에 regioselective Fischer indolization을 통하여 원하는 천연 물의 골격을 만들도록 계획하였다. 이후 몇 스텝을 통하여 원하는 천연물인 (±) tubifolidine를 만드는 것을 목표로 연구를 진행중이다. | - |
dc.publisher | 한양대학교 | - |
dc.title | Studies towards total synthesis of (±)tubifolidine via regioselective Fischer indolization | - |
dc.type | Theses | - |
dc.contributor.googleauthor | 김정화 | - |
dc.contributor.alternativeauthor | Kim, Jeong Hwa | - |
dc.sector.campus | S | - |
dc.sector.daehak | 대학원 | - |
dc.sector.department | 화학과 | - |
dc.description.degree | Master | - |
dc.contributor.affiliation | 유기화학 | - |
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