58 0

Aging extension and modifications of lipid metabolism in the monogonont rotifer Brachionus Koreanus under chronic caloric restriction

Title
Aging extension and modifications of lipid metabolism in the monogonont rotifer Brachionus Koreanus under chronic caloric restriction
Author
신경훈
Keywords
EXTENDS LIFE-SPAN; MANJAVACAS ROTIFERA; C. ELEGANS; GENE; SIR2; REPRODUCTION; EVOLUTION; COST; EXPRESSION; GENOME
Issue Date
2018-01
Publisher
NATURE PUBLISHING GROUP
Citation
SCIENTIFIC REPORTS, v. 8, Article no. 1741
Abstract
To examine the interrelationship of aging extension and modification of lipid metabolism under chronic caloric restriction (CCR; reduced concentration of the green algae Tetraselmis suecic alpha) in the monogonont rotifer Brachionus koreanus, we assessed life cycle parameters, fatty acid composition, and expression of sirtuin and genes related to lipid metabolism. B. koreanus in the 5% T. suecic alpha group showed an increased life span but decreased reproduction. Based on this finding, we chose 5% T. suecic alpha for further experiments and compared the data with those for 100% T. suecica. Upregulation of sirtuin gene expression was observed under CCR. In addition, despite the reduction in the amount of total fatty acid (FA) and the area of triacylglycerol, increases in the ratios of saturated fatty acid and monounsaturated fatty acid (MUFA) to total FA in 5%-exposed B. koreanus were observed. Furthermore, mRNA expression analysis confirmed that CCR promoted the synthesis of MUFA through Delta 9 desaturase. Moreover, expression of the docosahexaenoic acid (DHA) synthesizing gene Delta 4 desaturase was also upregulated, together with DHA content. These data suggest that CCR modified protein acetylation and lipid metabolism, leading to a decrease in reproduction and consequently resulting in life span extension.
URI
https://www.nature.com/articles/s41598-018-20108-7http://repository.hanyang.ac.kr/handle/20.500.11754/99194
ISSN
2045-2322
DOI
10.1038/s41598-018-20108-7
Appears in Collections:
COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > MARINE SCIENCE AND CONVERGENCE ENGINEERING(해양융합공학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE