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dc.contributor.author최한곤-
dc.date.accessioned2019-02-22T01:21:43Z-
dc.date.available2019-02-22T01:21:43Z-
dc.date.issued2018-12-
dc.identifier.citationJOURNAL OF MICROENCAPSULATION, v. 35, No. 5, Page. 421-427en_US
dc.identifier.issn0265-2048-
dc.identifier.issn1464-5246-
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/02652048.2018.1515997?-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/99152-
dc.description.abstractTo develop a novel revaprazan-loaded gelatine microsphere with enhanced solubility and oral bioavailability, numerous gelatine microspheres were prepared using a spray-drying technique. The impact of gelatine amount on drug solubility in the gelatine microspheres was investigated. The physicochemical properties of the selected gelatine microsphere, such as shape, particle size and crystallinity, were evaluated. Moreover, its dissolution and pharmacokinetics in rats were assessed in comparison with revaprazan powder. Amongst the gelatine microspheres tested, the gelatine microsphere consisting of revaprazan and gelatine (1:2, w/w), which gave about 150-fold increased solubility, had the most enhanced drug solubility. It provided a spherical shape, amorphous drug and reduced particle size. Furthermore, it gave a higher dissolution rate and plasma concentration than did revaprazan powder. Particularly, it gave about 2.3-fold improved oral bioavailability in comparison with revaprazan powder. Therefore, this novel gelatine microsphere system is recommended as an oral pharmaceutical product of poorly water-soluble revaprazan.en_US
dc.description.sponsorshipThis work was supported by National Research Foundation (NRF) of South Korea grants funded by the South Korea government (MEST) (no. 2018R1A2B2004668) and a grant (16173MFDS542) from the Ministry of Food and Drug Safety in 2016.en_US
dc.language.isoen_USen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.subjectGelatine microsphereen_US
dc.subjectrevaprazanen_US
dc.subjectspray-dryingen_US
dc.subjectdrug solubilityen_US
dc.subjectoral bioavailabilityen_US
dc.titleNovel revaprazan-loaded gelatin microsphere with enhanced drug solubility and oral bioavailabilityen_US
dc.typeArticleen_US
dc.relation.no5-
dc.relation.volume35-
dc.identifier.doi10.1080/02652048.2018.1515997-
dc.relation.page421-427-
dc.relation.journalJOURNAL OF MICROENCAPSULATION-
dc.contributor.googleauthorKim, Jung Suk-
dc.contributor.googleauthorPark, Jong Hyuck-
dc.contributor.googleauthorJeong, Sung Chan-
dc.contributor.googleauthorKim, Dong Shik-
dc.contributor.googleauthorYousaf, Abid Mehmood-
dc.contributor.googleauthorDin, Fakhar Ud-
dc.contributor.googleauthorKim, Jong Oh-
dc.contributor.googleauthorYong, Chul Soon-
dc.contributor.googleauthorYoun, Yu Seok-
dc.contributor.googleauthorChoi, Han-Gon-
dc.contributor.googleauthorOh, Kyung Taek-
dc.contributor.googleauthorJin, Sung Giu-
dc.relation.code2018001494-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidhangon-
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COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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