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Novel revaprazan-loaded gelatin microsphere with enhanced drug solubility and oral bioavailability

Title
Novel revaprazan-loaded gelatin microsphere with enhanced drug solubility and oral bioavailability
Author
최한곤
Keywords
Gelatine microsphere; revaprazan; spray-drying; drug solubility; oral bioavailability
Issue Date
2018-12
Publisher
TAYLOR & FRANCIS LTD
Citation
JOURNAL OF MICROENCAPSULATION, v. 35, No. 5, Page. 421-427
Abstract
To develop a novel revaprazan-loaded gelatine microsphere with enhanced solubility and oral bioavailability, numerous gelatine microspheres were prepared using a spray-drying technique. The impact of gelatine amount on drug solubility in the gelatine microspheres was investigated. The physicochemical properties of the selected gelatine microsphere, such as shape, particle size and crystallinity, were evaluated. Moreover, its dissolution and pharmacokinetics in rats were assessed in comparison with revaprazan powder. Amongst the gelatine microspheres tested, the gelatine microsphere consisting of revaprazan and gelatine (1:2, w/w), which gave about 150-fold increased solubility, had the most enhanced drug solubility. It provided a spherical shape, amorphous drug and reduced particle size. Furthermore, it gave a higher dissolution rate and plasma concentration than did revaprazan powder. Particularly, it gave about 2.3-fold improved oral bioavailability in comparison with revaprazan powder. Therefore, this novel gelatine microsphere system is recommended as an oral pharmaceutical product of poorly water-soluble revaprazan.
URI
https://www.tandfonline.com/doi/full/10.1080/02652048.2018.1515997?http://repository.hanyang.ac.kr/handle/20.500.11754/99152
ISSN
0265-2048; 1464-5246
DOI
10.1080/02652048.2018.1515997
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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