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dc.contributor.author배옥남-
dc.date.accessioned2019-01-25T07:14:04Z-
dc.date.available2019-01-25T07:14:04Z-
dc.date.issued2018-10-
dc.identifier.citationHUMAN & EXPERIMENTAL TOXICOLOGY, v. 37, No. 10, Page. 1025-1036en_US
dc.identifier.issn0960-3271-
dc.identifier.urihttps://journals.sagepub.com/doi/abs/10.1177/0960327117751234-
dc.identifier.urihttp://repository.hanyang.ac.kr/handle/20.500.11754/81445-
dc.description.abstractThe kidney is one of the main targets for toxicity induced by xenobiotics. Sensitive detection of early impairment is critical to assess chemical-associated renal toxicity. The aim of this study was to identify potential nephrotoxic biomarkers in rat kidney tissues after exposure to mercury (Hg), a representative nephrotoxicant, and to evaluate these new biomarkers employing in vivo and in vitro systems. Mercuric chloride was administered orally to Sprague-Dawley rats for 2 weeks. Proteomic analysis revealed that aldo-keto reductase (AKR7A1) and glutathione S-transferase pi (GSTP1) were significantly elevated in kidney after Hg exposure. While the levels of conventional nephrotoxic clinical markers including blood urea nitrogen and serum creatinine were not elevated, the mRNA and protein levels of AKR7A1 and GSTP1 were increased upon Hg exposure in a dose-dependent manner. The increases in AKR7A1 and GSTP1 were also observed in rat kidneys after an extended exposure for 6 weeks to low-dose Hg. In in vitro rat kidney proximal tubular cells, changes in AKR7A1 and GSTP1 levels correlated well with the extent of cytotoxicity induced by Hg, cadmium, or cisplatin. AKR7A1 and GSTP1 were identified as new candidates for Hg-induced nephrotoxicity, suggesting that these biomarkers have potential for evaluating or predicting nephrotoxicity.en_US
dc.description.sponsorshipThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by Ministry of Food and Drug Safety, Republic of Korea (grant nos. 12162MFDS736 and 15162MFDS045).en_US
dc.language.isoen_USen_US
dc.publisherSAGE PUBLICATIONS LTDen_US
dc.subjectNephrotoxicityen_US
dc.subjectbiomarkersen_US
dc.subjectpredictionen_US
dc.subjectAKR7A1en_US
dc.subjectGSTP1en_US
dc.titleIdentification of aldo-keto reductase(AKR7A1) and glutathione S-transferase pi (GSTP1) as novel renal damage biomarkers following exposure to mercuryen_US
dc.typeArticleen_US
dc.relation.no10-
dc.relation.volume37-
dc.identifier.doi10.1177/0960327117751234-
dc.relation.page1025-1036-
dc.relation.journalHUMAN & EXPERIMENTAL TOXICOLOGY-
dc.contributor.googleauthorShin, Y-J-
dc.contributor.googleauthorKim, K-A-
dc.contributor.googleauthorKim, E-S-
dc.contributor.googleauthorKim, J-H-
dc.contributor.googleauthorKim, H-S-
dc.contributor.googleauthorHa, M.-
dc.contributor.googleauthorBae, O-N-
dc.relation.code2018000964-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidonbae-
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COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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