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dc.contributor.author최한곤-
dc.date.accessioned2019-01-10T02:28:41Z-
dc.date.available2019-01-10T02:28:41Z-
dc.date.issued2018-07-
dc.identifier.citationCOLLOIDS AND SURFACES B-BIOINTERFACES, v. 171, Page. 123-133en_US
dc.identifier.issn0927-7765-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0927776518304636-
dc.identifier.urihttp://repository.hanyang.ac.kr/handle/20.500.11754/81211-
dc.description.abstractChlorin e6 (Ce6) has attracted considerable interest as a promising second-generation photosensitizer for photodynamic therapy (PDT). However, the in vivo availability of Ce6 is significantly restricted by its low water solubility and poor ability to target tumors. We sought to overcome the limitations of Ce6 by using albumin nanoparticles with nab (TM) (nanoparticle albumin-bound) technology. The fabricated albumin nanoparticles consisted of bovine serum albumin (BSA), Ce6-BSA, and beta-carotene as a carrier, photosensitizing agent, and cross-linker, respectively. These albumin nanoparticles (Ce6-BSA-BC-NPs) did not include any toxic chemotherapeutics but instead contained naturally safe beta-carotene and Ce6, which was activated only upon irradiation with 660-nm laser light. Ce6-BSA-BC-NPs were similar to 120 nm in size and spherical, similar to Abraxane (R), and showed good physicochemical stability. The nanoparticles showed significant cytotoxicity toward 4T1 cells as evaluated by MTT, Live/Dead, and TUNEL assays. In particular, results of the TUNEL assay demonstrated that cell death induced by Ce6-BSA-BC-NPs and light irradiation (660 nm) occurred through the apoptotic pathway. Ce6-BSA-BC-NPs displayed a remarkably enhanced tumor suppression effect when irradiated by 660-nm light compared with free Ce6 (tumor volume 90 +/- 39 versus 487 +/- 69 mm(3) respectively). Overall, this improved in vivo antitumor efficacy seemed to be due to the targetability of albumin nanoparticles. We believe that our Ce6-BSA-BC-NPs with PDT offer a promising new potential therapeutic platform for breast cancer treatment.en_US
dc.description.sponsorshipThis research was supported by a grant (16173MFDS542) from the Ministry of Food and Drug Safety in 2018.en_US
dc.language.isoen_USen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.subjectBeta-caroteneen_US
dc.subjectPhotodynamic therapyen_US
dc.subjectChlorin e6en_US
dc.subjectNanoparticlesen_US
dc.subjectAlbuminen_US
dc.subjectTumor targetingen_US
dc.titleBeta-carotene-bound albumin nanoparticles modified with chlorin e6 for breast tumor ablation based on photodynamic therapyen_US
dc.typeArticleen_US
dc.relation.volume171-
dc.identifier.doi10.1016/j.colsurfb.2018.07.016-
dc.relation.page123-133-
dc.relation.journalCOLLOIDS AND SURFACES B-BIOINTERFACES-
dc.contributor.googleauthorPhuong, Pham Thi Thu-
dc.contributor.googleauthorLee, Sungin-
dc.contributor.googleauthorLee, Changkyu-
dc.contributor.googleauthorSeo, Bohyung-
dc.contributor.googleauthorPark, Sanghyun-
dc.contributor.googleauthorOh, Kyung Taek-
dc.contributor.googleauthorLee, Eun Seong-
dc.contributor.googleauthorChoi, Han-Gon-
dc.contributor.googleauthorShin, Beom Soo-
dc.contributor.googleauthorYoun, Yu Seok-
dc.relation.code2018001466-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidhangon-
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COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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