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Bisphenol A distribution in serum, urine, placenta, breast milk, and umbilical cord serum in a birth panel of mother-neonate pairs

Title
Bisphenol A distribution in serum, urine, placenta, breast milk, and umbilical cord serum in a birth panel of mother-neonate pairs
Author
문효방
Keywords
Bisphenol A; Pregnant women; Neonates; Tissue distribution; BPA ratio
Issue Date
2018-06
Publisher
ELSEVIER SCIENCE BV
Citation
SCIENCE OF THE TOTAL ENVIRONMENT, v. 626, Page. 1494-1501
Abstract
Bisphenol A (BPA) exposure during the perinatal and postnatal periods increases the susceptibility to disease over the life cycle. However, information on the BPA delivered to fetuses or infants via the placenta and breastfeeding is limited. We determined the BPA exposure levels in various bodily fluids and tissues of pregnant women and described fetus and infant exposures to BPA based on associations and BPA ratios inmother-neonate paired samples. Maternal serum, urine, placenta, breast milk, cord serum, and neonatal urine samples were collected from 318mother-neonate pairs at six university hospitals in Korea. BPA levelswere detected using liquid chromatography tandemmass spectrometry. The ratios of the BPA levels in the other sample types to the levels in maternal serumwere calculated. BPA was detected in 79.5-100% of the maternal and fetal samples. The median BPA concentration in the samples decreased in the order of neonatal urine (4.75 ng/mL), maternal urine (2.86 ng/mL), cord serum(1.71 ng/mL), maternal serum (1.56 ng/mL), breast milk (0.74 ng/mL), and the placenta (0.53 ng/g). We estimated the ratios of BPA levels in the other sample types to those in maternal serum. The median (95th percentile) cord serum-to-maternal serum ratio was 1.12 (15.2) for 160 mother-fetal pairs, in which BPA was detected in both samples. The placenta-, maternal urine-, neonatal urine-, and breast milk-tomaternal serum ratios were 0.28 (5.31), 1.79 (29.9), 1.98 (28.2), and 0.51 (10.5), respectively. In addition, the median (95th percentile) cord serum-to-placenta ratio was 4.03 (45.8), and the neonatal urine-to-cord serum ratio was 1.95 (25.6). The 95th percentile values were 14-20-fold greater than the medians. Urine contained the highest BPA concentrations, followed by serum, breast milk, and the placenta. The variations of BPA ratio show individual differences in the amounts of BPA delivered from mother to fetus. (c) 2017 Published by Elsevier B.V.
URI
https://www.sciencedirect.com/science/article/pii/S0048969717327456http://repository.hanyang.ac.kr/handle/20.500.11754/81161
ISSN
0048-9697
DOI
10.1016/j.scitotenv.2017.10.042
Appears in Collections:
COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > MARINE SCIENCE AND CONVERGENCE ENGINEERING(해양융합공학과) > Articles
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