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Short-term inhalation study of graphene oxide nanoplates

Title
Short-term inhalation study of graphene oxide nanoplates
Author
안강호
Keywords
Graphene oxide; short-term inhalation study; toxicology; nose-only inhalation exposure system
Issue Date
2018-06
Publisher
TAYLOR & FRANCIS LTD
Citation
NANOTOXICOLOGY, v. 12, No. 3, Page. 224-238
Abstract
Graphene oxides possess unique physicochemical properties with important potential applications in electronics, pharmaceuticals, and medicine. However, the toxicity following inhalation exposure to graphene oxide has not yet been clarified. Therefore, this study conducted a short-term graphene oxide inhalation toxicity analysis using a nose-only inhalation exposure system and male Sprague-Dawley rats. A total of four groups (15 rats per group) were exposed: (1) control (fresh air), (2) low concentration (0.76 +/- 0.16 mg/m(3)), (3) moderate concentration (2.60 +/- 0.19 mg/m(3)), and (4) high concentration (9.78 +/- 0.29 mg/m(3)). The rats were exposed to graphene oxide for 6 h/day for 5 days, followed by recovery for 1, 3, and 21 days. No significant body or organ weight changes were noted after the short-term exposure or during the recovery period. Similarly, no significant systemic effects of toxicological importance were noted in the hematological assays, bronchoalveolar lavage fluid (BAL) inflammatory markers, BAL fluid cytokines, or blood biochemical assays following the graphene oxide exposure or during the post-exposure observation period. Moreover, no significant differences were observed in the BAL cell differentials, such as lymphocytes, macrophages, or polymorphonuclear cells. Graphene oxide-ingested alveolar macrophages as a spontaneous clearance reaction were observed in the lungs of all the concentration groups from post 1 day to post 21 days. Histopathological examination of the liver and kidneys did not reveal any significant test-article-relevant histopathological lesions. Importantly, similar to previously reported graphene inhalation data, this short-term nose-only inhalation study found only minimal or unnoticeable graphene oxide toxicity in the lungs and other organs.
URI
https://www.tandfonline.com/doi/abs/10.1080/17435390.2018.1431318http://repository.hanyang.ac.kr/handle/20.500.11754/81109
ISSN
1743-5390
DOI
10.1080/17435390.2018.1431318
Appears in Collections:
COLLEGE OF ENGINEERING SCIENCES[E](공학대학) > MECHANICAL ENGINEERING(기계공학과) > Articles
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