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Development of a docetaxel micellar formulation using poly(ethyleneglycol)–polylactide–poly(ethylene glycol) (PEG–PLA–PEG) with successful reconstitution for tumor targeted drug delivery

Title
Development of a docetaxel micellar formulation using poly(ethyleneglycol)–polylactide–poly(ethylene glycol) (PEG–PLA–PEG) with successful reconstitution for tumor targeted drug delivery
Author
최한곤
Keywords
Nanomedicine; lyophilization; cancer; reconstitution; polymeric micelle
Issue Date
2018-06
Publisher
TAYLOR & FRANCIS LTD
Citation
DRUG DELIVERY, v. 25, No. 1, Page. 1362-1371
Abstract
Docetaxel (DTX)-loaded polymeric micelles (DTBM) were formulated using the triblock copolymer, poly(ethylene glycol)-polylactide-poly(ethylene glycol) (PEG-PLA-PEG), to comprehensively study their pharmaceutical application as anticancer nanomedicine. DTBM showed a stable formulation of anticancer nanomedicine that could be reconstituted after lyophilization (DTBM-R) in the presence of PEG 2000 and D-mannitol (Man) as surfactant and protectant, respectively. DTBM-R showed a particle size less than 150nm and greater than 90% of DTX recovery after reconstitution. The robustly formed micelles might minimize systemic toxicity due to their sustained drug release and also maximize antitumor efficacy through increased accumulation and release of DTX from the micelles. From the pharmaceutical development point of view, DTBM-R showing successful reconstitution could be considered as a potent nanomedicine for tumor treatment.
URI
https://www.tandfonline.com/doi/abs/10.1080/10717544.2018.1477865http://repository.hanyang.ac.kr/handle/20.500.11754/81097
ISSN
1071-7544
DOI
10.1080/10717544.2018.1477865
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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