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dc.contributor.author정지은-
dc.date.accessioned2019-01-07T04:50:38Z-
dc.date.available2019-01-07T04:50:38Z-
dc.date.issued2018-06-
dc.identifier.citationBMC GENETICS, v. 19, Article no. 47en_US
dc.identifier.issn1471-2156-
dc.identifier.urihttps://bmcgenet.biomedcentral.com/articles/10.1186/s12863-018-0658-z-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/81093-
dc.description.abstractBackground: The present study aimed to investigate the association between MKRN3 and LIN28B gene polymorphisms and precocious puberty in Korean boys and girls. Results: Children 7 to 9 years of age in 2011 to 2012 who were part of the Ewha Birth Growth Cohort Study were recruited for this study. A total of 103 girls and 70 boys were included in the analyses. Seven girls and 26 boys were identified to have precocious puberty. Among four single nucleotide polymorphisms (SNPs) of MKRN3 and two SNPs of LIN28B examined, three SNPs (rs2239669, rs6576457, and rs12441827) showed significant associations with precocious puberty in additive models in boys but no significance was found in any SNPs in girls. From the logistic regression analysis, boys with TT alleles in rs12441827 had about a four-times greater risk for precocious puberty when compared to C allele carriers (OR = 3.95, 95% CI = 1.27-1232 in model 1). eQTL analysis revealed that SNPs of statistical significance from our study did not show the variation in expression profiles nor found in the database. Conclusions: This study supports the impact of MKRN3 SNP rs12441827 on precocious puberty in Korean boys. The results add a further aspect to genetic association in precocious puberty along with complex interactions of environmental, nutritional and socioeconomic factors.en_US
dc.description.sponsorshipThis work was supported by the National Research Foundation of Korea Grant funded by the Korean Government (No. 2010-0026225). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en_US
dc.language.isoen_USen_US
dc.publisherBIOMED CENTRAL LTDen_US
dc.subjectPrecocious pubertyen_US
dc.subjectMakorin RING finger protein 3en_US
dc.subjectLin-28 homolog Ben_US
dc.subjectSingle nucleotide polymorphismen_US
dc.titleAssociation between MKRN3 and LIN28B polymorphisms and precocious pubertyen_US
dc.typeArticleen_US
dc.relation.volume19-
dc.identifier.doi10.1186/s12863-018-0658-z-
dc.relation.page47-54-
dc.relation.journalBMC GENETICS-
dc.contributor.googleauthorYi, Bo Ram-
dc.contributor.googleauthorKim, Hyun Jeong-
dc.contributor.googleauthorPark, Hye Sook-
dc.contributor.googleauthorCho, Yoon Jeong-
dc.contributor.googleauthorKim, Ju Young-
dc.contributor.googleauthorYee, Jeong-
dc.contributor.googleauthorChung, Jee Eun-
dc.contributor.googleauthorKim, Joo Hee-
dc.contributor.googleauthorLee, Kyung Eun-
dc.contributor.googleauthorGwak, Hye Sun-
dc.relation.code2018006215-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidjechung-
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COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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