32 0

Hypervalent iodine-mediated Ritter-type amidation of terminal alkenes: The synthesis of isoxazoline and pyrazoline cores

Title
Hypervalent iodine-mediated Ritter-type amidation of terminal alkenes: The synthesis of isoxazoline and pyrazoline cores
Author
남태규
Keywords
amido-amidation; hypervalent iodine; isoxazoline; metal-free; oxyamidation; pyrazoline
Issue Date
2018-05
Publisher
BEILSTEIN-INSTITUT
Citation
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, v. 14, Page. 1028-1033
Abstract
Hypervalent iodine-mediated olefin functionalization provides a rapid gateway towards accessing both various heterocyclic cores and functional groups. In this regard, we have developed a Ritter-type alkene functionalization utilizing a PhI(OAc)(2) ((diacetoxyiodo) benzene, PIDA)/Lewis acid combination in order to access isoxazoline and pyrazoline cores. Based on allyl ketone oximes and allyl ketone tosylhydrazones, we have developed an alkene oxyamidation and amido-amidation protocol en route to accessing both isoxazoline and pyrazoline cores. Additionally, acetonitrile serves as both the solvent and an amine source in the presence of this PIDA/Lewis acid combination. This operationally straightforward and metal-free protocol provides an easy access to isoxazoline and pyrazoline derivatives.
URI
https://www.beilstein-journals.org/bjoc/articles/14/89http://repository.hanyang.ac.kr/handle/20.500.11754/81039
ISSN
1860-5397
DOI
10.3762/bjoc.14.89
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE