Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최한곤 | - |
dc.date.accessioned | 2018-12-14T00:55:55Z | - |
dc.date.available | 2018-12-14T00:55:55Z | - |
dc.date.issued | 2008-12 | - |
dc.identifier.citation | ARCHIVES OF PHARMACAL RESEARCH, v. 31, No. 12, Page. 1652-1658 | en_US |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.uri | https://link.springer.com/article/10.1007/s12272-001-2164-4 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/80858 | - |
dc.description.abstract | Transdermal formulation of L-ascorbic acid 2-phosphate magnesium salt (A2P) was prepared using multilamellar vesicles (MLV). A2P was either physically mixed with or entrapped into three different MLVs of neutral, cationic, and anionic liposome vesicles. For the preparation of neutral MLVs, phosphatidylcholine (PC) and cholesterol (CH) were used. For cationic and anionic MLVs, dioleoyl-trimethylammonium-propane and dimyristoyl glycerophosphate were added as surface charge inducers, respectively, in addition to PC and CH. Particle size of the three A2P-loaded MLVs was submicron, and polydispersity index revealed homogenous distribution of the prepared MLVs except neutral ones. Skin penetration study with hairless mouse skin showed that both physical mixtures of A2P with empty MLVs and A2P-loaded MLVs increased penetration of the drug compared to aqueous A2P solution. During the penetration, however, significant amount of the drug was metabolized into L-ascorbic acid, which has no beneficial effect on stimulation of hair growth. Out of the physical mixtures and A2P-loaded MLVs tested, physical mixture of A2P with empty cationic MLV resulted in the greatest skin penetration and retention in hairless mouse skin. | en_US |
dc.description.sponsorship | This work was supported by Korea Research Foundation Grant funded by the Korean Government (MOEHRD, Basic Research Promotion Fund) (KRF-2007-314-E00246). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | PHARMACEUTICAL SOCIETY KOREA | en_US |
dc.subject | Alopecia | en_US |
dc.subject | L-Ascorbic acid-2-phosphate | en_US |
dc.subject | L-Ascorbic acid | en_US |
dc.subject | Liposome | en_US |
dc.subject | Phosphatidylcholine | en_US |
dc.title | Skin penetration and retention of L-Ascorbic acid 2-phosphate using multilamellar vesicles | en_US |
dc.type | Article | en_US |
dc.relation.volume | 31 | - |
dc.identifier.doi | 10.1007/s12272-001-2164-4 | - |
dc.relation.page | 1652-1658 | - |
dc.relation.journal | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.contributor.googleauthor | Yoo, Juno | - |
dc.contributor.googleauthor | Shanmugam, Srinivasan | - |
dc.contributor.googleauthor | Song, Chung-Kil | - |
dc.contributor.googleauthor | Kim, Dae-Duk | - |
dc.contributor.googleauthor | Choi, Han-Gon | - |
dc.contributor.googleauthor | Yong, Chul-Soon | - |
dc.contributor.googleauthor | Woo, Jong-Soo | - |
dc.contributor.googleauthor | Yoo, Bong Kyu | - |
dc.relation.code | 2008200969 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | hangon | - |
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