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Prion propagation in vitro: Are we there yet?

Title
Prion propagation in vitro: Are we there yet?
Author
류종석
Keywords
Cellular prion protein; Disease-associated scrapie prion protein; In vitro conversion; In vitro prion amplification; Prion; Prion disease; Prion infectivity
Issue Date
2008-11
Publisher
Ivyspring International Publisher
Citation
International Journal of Medical Sciences, v. 5, No. 6, Page. 347-353
Abstract
Prion diseases are caused by proteinaceous pathogens termed prions. Although the details of the mechanism of prion propagation are not fully understood, conformational conversion of cellular prion protein (PrP C) to misfolded, disease-associated scrapie prion protein (PrP Sc) is considered the essential biochemical event for prion replication. Currently, studying prion replication in vitro is difficult due to the lack of a system which fully recapitulates the in vivo phenomenon. Over the last 15 years, a number of in vitro systems supporting PrPC conversion, PrPSc amplification, or amyloid fibril formation have been established. In this review, we describe the evolving methodology of in vitro prion propagation assays and discuss their ability in reflecting prion propagation in vivo. © Ivyspring International Publisher. All rights reserved.
URI
http://www.medsci.org/v05p0347.htmhttp://repository.hanyang.ac.kr/handle/20.500.11754/80766
ISSN
1449-1907
DOI
10.7150/ijms.5.347
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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